非氨酯及其他抗惊厥药物对大鼠两种癫痫持续状态模型的作用。

Effects of felbamate and other anticonvulsant drugs in two models of status epilepticus in the rat.

作者信息

Sofia R D, Gordon R, Gels M, Diamantis W

机构信息

Wallace Laboratories, Division of Carter-Wallace, Inc., Cranbury, New Jersey 08512.

出版信息

Res Commun Chem Pathol Pharmacol. 1993 Mar;79(3):335-41.

PMID:8480078

Abstract

Felbamate was compared with several antiepileptic drugs for protective effects in two rat models of status epilepticus. Felbamate was ten times more potent against pilocarpine-induced seizures in lithium-treated rats than in lithium-free animals. Diazepam, valproate and phenobarbital were effective in both the high dose pilocarpine and lithium-pilocarpine models. On the other hand, phenytoin was ineffective in both models, whereas carbamazepine displayed protective effects only in the lithium-pilocarpine model.

摘要

在两种癫痫持续状态大鼠模型中，对非氨酯与几种抗癫痫药物的保护作用进行了比较。在锂处理的大鼠中，非氨酯对毛果芸香碱诱发癫痫的效力比对未用锂处理动物的效力强10倍。地西泮、丙戊酸盐和苯巴比妥在高剂量毛果芸香碱模型和锂-毛果芸香碱模型中均有效。另一方面，苯妥英在两种模型中均无效，而卡马西平仅在锂-毛果芸香碱模型中显示出保护作用。