DXS539, a polymorphic DNA marker proximal of the fragile-X gene.
作者信息
Dreesen J C, van den Hurk J A, Smits A P, van den Ouweland A M, Markslag P W, van Oost B A
机构信息
Department of Human Genetics, University Hospital Nijmegen, The Netherlands.
出版信息
Hum Genet. 1993 Mar;91(1):80-2. doi: 10.1007/BF00230229.
PMID:8454292
Abstract
We report a new polymorphic DNA marker (pJH89, DXS539) proximal to the fragile-X site. The pJH89 probe identifies a TaqI and a NcoI restriction fragment length polymorphism (combined heterozygosity of 42%) and is linked to the fragile-X locus with a maximal LOD score of 12 at 4 cM. Multipoint linkage analysis and physical mapping studies indicate that the pJH89 probe is located within in the interval defined by the markers DXS369 and DXS548.
摘要
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