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D21S210: a highly polymorphic (GT)n marker closely linked to the beta-amyloid protein precursor (APP) gene.

作者信息

Warren A C, McInnis M G, Kalaitsidaki M, Cox T K, Blaschak J, Chakravarti A, Antonarakis S E

机构信息

Center for Medical Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205.

出版信息

Hum Genet. 1993 Mar;91(1):87-8. doi: 10.1007/BF00230232.

DOI:10.1007/BF00230232
PMID:8454294
Abstract

We describe a highly polymorphic (GT)n repeat with 14 alleles that is closely linked to the amyloid precursor protein (APP) gene on human chromosome 21. This marker, D21S210, will be useful for studies of linkage of disorders such as Alzheimer disease to the APP gene.

摘要

相似文献

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2
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A large, dominant pedigree of atrioventricular septal defect (AVSD): exclusion from the Down syndrome critical region on chromosome 21.一个大型的、具有主导性的房室间隔缺损(AVSD)家系:排除21号染色体上的唐氏综合征关键区域。
Am J Hum Genet. 1993 Dec;53(6):1262-8.
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Genetic and physical mapping of the GLUR5 glutamate receptor gene on human chromosome 21.
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本文引用的文献

1
An efficient method for selecting unique-sequence clones from DNA libraries and its application to fluorescent staining of human chromosome 21 using in situ hybridization.一种从DNA文库中筛选独特序列克隆的有效方法及其在人21号染色体荧光原位杂交染色中的应用。
Genomics. 1989 Jul;5(1):100-9. doi: 10.1016/0888-7543(89)90092-x.
A population-based study of familial Alzheimer disease: linkage to chromosomes 14, 19, and 21.一项基于人群的家族性阿尔茨海默病研究:与14号、19号和21号染色体的连锁关系。
Am J Hum Genet. 1994 Oct;55(4):714-27.
5
Molecular mapping of 21 features associated with partial monosomy 21: involvement of the APP-SOD1 region.与21号染色体部分单体相关的21个特征的分子图谱:淀粉样前体蛋白-超氧化物歧化酶1区域的累及情况
Am J Hum Genet. 1995 Jul;57(1):62-71.