位于11号染色体11q23区域的D11S29位点存在高信息量的二核苷酸重复多态性。
Highly informative dinucleotide repeat polymorphism at the D11S29 locus on chromosome 11q23.
作者信息
Warnich L, Groenewald I, Theart L, Retief A E
机构信息
Department of Human Genetics, Tygerberg Hospital, Republic of South Africa.
出版信息
Hum Genet. 1992 May;89(3):357-9. doi: 10.1007/BF00220560.
PMID:1601428
Abstract
The informativeness of locus D11S29 as a genetic marker was improved by the identification of a highly polymorphic (GT)n repeat within the locus. Ten alleles were identified in parents of 40 Centre d'Etude du Polymorphisme Humain families and the polymorphism information content (PIC) was 0.77. The increased PIC value thus enables refinement of the linkage map of 11q23.
摘要
通过在基因座D11S29内鉴定出高度多态的(GT)n重复序列，提高了该基因座作为遗传标记的信息含量。在40个法国人类多态性研究中心家族的父母中鉴定出了10个等位基因，多态信息含量（PIC）为0.77。因此，增加的PIC值能够完善11q23的连锁图谱。
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