Ryffel B, Mihatsch M J, Woerly G
Institut für Toxikologie, Eidgenössischen Technischen Hochschule Universität Zürich, Switzerland.
Int Rev Exp Pathol. 1993;34 Pt A:79-89.
Interleukin-6 (IL-6) is a multifunctional cytokine that plays an important role in the immune response, hemopoiesis, and host defense. Recombinant human IL-6 (rhIL-6) was administered at high doses to mice, rats, and nonhuman primates. In all species, IL-6 had an immunostimulatory and hemopoietic (especially on megakaryocytes) effect. An acute-phase response was most pronounced in nonhuman primates, which was, however, not associated with any significant histopathological liver change. Finally, no evidence of glomerular pathology was found. Neutralizing antibodies were detected within 10 days of rhIL-6 administration in all species.
白细胞介素-6（IL-6）是一种多功能细胞因子，在免疫反应、造血和宿主防御中发挥重要作用。已将重组人IL-6（rhIL-6）以高剂量给予小鼠、大鼠和非人类灵长类动物。在所有物种中，IL-6均具有免疫刺激和造血（尤其是对巨核细胞）作用。急性期反应在非人类灵长类动物中最为明显，然而，这与任何明显的肝脏组织病理学变化均无关。最后，未发现肾小球病变的证据。在所有物种中，rhIL-6给药后10天内均检测到中和抗体。
