Newton M R, Austin M C, Chan J G, McKay W J, Rowe C C, Berkovic S F
Department of Nuclear Medicine, Austin Hospital, Melbourne, Victoria, Australia.
J Nucl Med. 1993 Apr;34(4):666-70.
Ictal SPECT provides unique information for the clinician treating patients with refractory epilepsy and reveals insights into the pathophysiology of seizures. We describe our methods for the routine attainment of ictal images using 99mTc-HMPAO. We have devised and implemented techniques for rapid reconstitution of 99mTc-HMPAO adjacent to the video-EEG monitoring suite such that the tracer can be rapidly injected into patients when spontaneous seizures occur. Our quality assurance data show that this can be done safely outside a nuclear medicine department. The clinical results in patients with temporal lobe epilepsy show that ictal injections (97% correct lateralization of focus, 0% incorrect) are more sensitive and accurate compared to interictal studies (48% correct, 10% incorrect), demonstrating that the implementation of these techniques is worthwhile.
发作期单光子发射计算机断层扫描（ictal SPECT）为治疗难治性癫痫的临床医生提供了独特信息，并揭示了癫痫发作的病理生理学见解。我们描述了使用99mTc-六甲基丙烯胺肟（99mTc-HMPAO）常规获取发作期图像的方法。我们设计并实施了在视频脑电图监测室附近快速配制99mTc-HMPAO的技术，以便在自发癫痫发作时能迅速将示踪剂注入患者体内。我们的质量保证数据表明，这可以在核医学科以外安全地进行。颞叶癫痫患者的临床结果显示，与发作间期研究相比（正确定位率48%，错误率10%），发作期注射（病灶定位正确率97%，无错误）更敏感、准确，表明实施这些技术是值得的。
