Lennon C, Davidson K W, Sadowski J A, Mason J B
Adult Nutrition Support Service, New England Medical Center, Boston.
JPEN J Parenter Enteral Nutr. 1993 Mar-Apr;17(2):142-4. doi: 10.1177/0148607193017002142.
Commercially available intravenous lipid emulsions are largely derived from vegetable oils, a natural source of phylloquinone (vitamin K1). We therefore examined the concentration of vitamin K1 in two widely used intravenous lipid emulsions by using a previously validated high performance liquid chromatography technique. The vitamin K1 concentrations of 10% emulsions of Intralipid and Liposyn II were 30.8 and 13.2 micrograms/dL, respectively. The concentration of vitamin K1 in the 20% emulsions of these products was essentially double that in the 10% emulsions. The coefficients of variation between the vitamin K1 content in three different lots of each product were consistently less than 7.0%. The observed concentrations of the vitamin in these lipid emulsions paralleled the predicted content on the basis of the type of vegetable oil(s) used to make the product. The type of vegetable oil used for production therefore seems to be a major determinant of the final vitamin K1 content. The vitamin K1 contained in these intravenous lipid emulsions is substantial and may have great impact on the vitamin K status of the recipient.
市售静脉注射用脂肪乳剂主要来源于植物油，而植物油是叶绿醌（维生素K1）的天然来源。因此，我们采用先前验证的高效液相色谱技术检测了两种广泛使用的静脉注射用脂肪乳剂中维生素K1的浓度。英脱利匹特10%乳剂和力保肪宁II 10%乳剂的维生素K1浓度分别为30.8微克/分升和13.2微克/分升。这两种产品20%乳剂中的维生素K1浓度基本上是10%乳剂的两倍。每种产品三个不同批次的维生素K1含量之间的变异系数始终小于7.0%。在这些脂肪乳剂中观察到的维生素浓度与根据用于生产该产品的植物油类型预测的含量相符。因此，用于生产的植物油类型似乎是最终维生素K1含量的主要决定因素。这些静脉注射用脂肪乳剂中所含的维生素K1含量可观，可能会对接受者的维生素K状态产生重大影响。
