Booth S L, Davidson K W, Lichtenstein A H, Sadowski J A
Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA.
Lipids. 1996 Jul;31(7):709-13. doi: 10.1007/BF02522886.
Dihydro-vitamin K1 is a dietary form of vitamin K1 (phylloquinone) produced during the hydrogenation of vegetable oils. To determine if dihydro-vitamin K1 is present in plasma following dietary intake of a hydrogenated fat, eight healthy adults consumed each of two diets containing 30% of calories from fat, of which 20% was either soybean oil or a partially hydrogenated soybean oil-based stick margarine. Of the fats and oils analyzed, dihydro-vitamin K1 was only found in the hydrogenated products. The soybean oil diet contained 180 +/- 12 micrograms (mean +/- SD) of vitamin K1/day and nondetectable levels of dihydro-vitamin K1, whereas the stick margarine diet contained 199 +/- 7 micrograms of vitamin K1/day and 23 +/- 2 micrograms of dihydro-vitamin K1/day. After consuming each diet for five weeks, plasma dihydro-vitamin K1 concentrations were higher (P = 0.002) in all eight subjects when consuming the stick margarine diet (0.56 +/- 0.33 nmol/L) compared to the soybean oil diet (0.12 +/- 0.11 nmol/L). There was no significant change in plasma vitamin K1 concentrations when the two diets were compared. In conclusion, dihydro-vitamin K1 is detectable in plasma following dietary intake of a hydrogenated vitamin K1-rich vegetable oil.
二氢维生素K1是植物油氢化过程中产生的维生素K1（叶绿醌）的一种膳食形式。为了确定摄入氢化脂肪后血浆中是否存在二氢维生素K1，8名健康成年人分别食用了两种脂肪供能占30%的膳食，其中20%的脂肪来源为大豆油或一种以部分氢化大豆油为基础的棒状人造黄油。在所分析的油脂中，仅在氢化产品中发现了二氢维生素K1。大豆油膳食中维生素K1的含量为每天180±12微克（均值±标准差），未检测到二氢维生素K1；而棒状人造黄油膳食中维生素K1的含量为每天199±7微克，二氢维生素K1的含量为每天23±2微克。在食用每种膳食5周后，与食用大豆油膳食（0.12±0.11纳摩尔/升）相比，所有8名受试者在食用棒状人造黄油膳食（0.56±0.33纳摩尔/升）时血浆中二氢维生素K1的浓度更高（P = 0.002）。比较两种膳食时，血浆中维生素K1浓度没有显著变化。总之，可以检测到在膳食中摄入富含氢化维生素K1植物油后血浆中的二氢维生素K1
