Martin L
J Endocrinol. 1977 Feb;72(2):181-5. doi: 10.1677/joe.0.0720181.
Single injections of oestriol were partially effective in sensitizing the uterus to a decidual stimulus and inducing ovum-implantation in progesterone-treated spayed mice, whereas two injections (6 h apart) were fully effective. It seems that in the progestational uterus, as in the non-progestational organ, oestriol can induce a full oestrogenic response provided that its level in the target organ is maintained. It is also concluded that ovum-implantation is not triggered by some transient early effect of oestrogen, but requires about 12 h of sustained oestrogen action for its successful completion.
单次注射雌三醇对使子宫对蜕膜刺激敏感并在经孕酮处理的去卵巢小鼠中诱导卵子着床有部分效果，而两次注射（间隔6小时）则完全有效。似乎在孕激素作用的子宫中，如同在非孕激素作用的器官中一样，只要其在靶器官中的水平得以维持，雌三醇就能诱导完全的雌激素反应。还得出结论，卵子着床不是由雌激素的某种短暂早期效应触发的，而是需要约12小时的持续雌激素作用才能成功完成。
