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蝾螈( Triturus )再生前肢中DNA合成的神经营养刺激作用

Neurotrophic stimulation of DNA synthesis in the regenerating forelimb of the newt, Triturus.

作者信息

Jabaily J A, Singer M

出版信息

J Exp Zool. 1977 Feb;199(2):251-6. doi: 10.1002/jez.1401990209.

DOI:10.1002/jez.1401990209
PMID:845581
Abstract

The effect of infusions of soluble newt brain extracts on deoxyribonucleic acid (DNA) synthesis in the denervated, regenerating newt blastema has been studied. When moderate early to early regenerates are denervated for 48 hours, DNA synthesis normally drops to about 40% of that found in contralateral, innervated blastemas. Infusion of brain extract halfway through the denervation period (at 24 hours) approximately doubles the rate of DNA synthesis in denervated regenerates.

摘要

已研究了可溶性蝾螈脑提取物输注对去神经支配的、正在再生的蝾螈芽基中脱氧核糖核酸(DNA)合成的影响。当将中度早期至早期再生的蝾螈去神经支配48小时时,DNA合成通常降至对侧有神经支配的芽基中DNA合成量的约40%。在去神经支配期的中途(24小时时)输注脑提取物,可使去神经支配的再生蝾螈的DNA合成速率增加约一倍。

相似文献

1
Neurotrophic stimulation of DNA synthesis in the regenerating forelimb of the newt, Triturus.蝾螈( Triturus )再生前肢中DNA合成的神经营养刺激作用
J Exp Zool. 1977 Feb;199(2):251-6. doi: 10.1002/jez.1401990209.
2
Ganglia implantation as a means of supplying neurotrophic stimulation to the newt regeneration blastema: cell-cycle effects in innervated and denervated limbs.神经节植入作为向蝾螈再生芽基提供神经营养刺激的一种手段:在有神经支配和去神经支配肢体中的细胞周期效应
J Exp Zool. 1992 Apr 15;262(1):71-80. doi: 10.1002/jez.1402620110.
3
Neurotrophic activity of brain extracts in forelimb regeneration of the urodele, Triturus.脑提取物对有尾目动物蝾螈前肢再生的神经营养活性。
J Exp Zool. 1976 May;196(2):131-50. doi: 10.1002/jez.1401960202.
4
Nerve extracts and substance P activate the phosphatidylinositol signaling pathway and mitogenesis in newt forelimb regenerates.
Dev Biol. 1995 Jan;167(1):239-51. doi: 10.1006/dbio.1995.1020.
5
Neurotrophic dependence of macromolecular synthesis in the early limb regenerate of the newt, Triturus.
J Embryol Exp Morphol. 1972 Aug;28(1):1-11.
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Mitotic activity and nucleic acid precursor incorporation in denervated and innervated limb stumps of axolotl larvae.墨西哥钝口螈幼虫去神经和有神经支配的肢体残端中的有丝分裂活性及核酸前体掺入情况。
J Exp Zool. 1976 Feb;195(2):253-62. doi: 10.1002/jez.1401950210.
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Newt forelimb regeneration blastemas in vitro: cellular response to explanation and effects of various growth-promoting substances.蝾螈前肢再生芽基的体外培养:细胞对解离的反应及各种促生长物质的作用
J Exp Zool. 1981 May;216(2):235-45. doi: 10.1002/jez.1402160204.
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The protective action of zinc against the deleterious effects of cadmium in the regenerating forelimb of the adult newt, Notophthalmus viridescens.锌对成年绿红东美螈再生前肢中镉的有害影响的保护作用。
Growth. 1977 Jun;41(2):95-103.
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Morphogenesis of the carpal elements in the regenerating forelimb of adult Notophthalmus viridescens viridescens.成年绿红东美螈再生前肢中腕骨元件的形态发生。
Anat Rec. 1975 Nov;183(3):421-9. doi: 10.1002/ar.1091830306.
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Hyaluronidase activity and glycosaminoglycan synthesis in the amputated newt limb: comparison of denervated, nonregenerating limbs with regenerates.蝾螈截肢肢体中的透明质酸酶活性和糖胺聚糖合成:去神经、不再生肢体与再生肢体的比较
Dev Biol. 1975 Apr;43(2):221-32. doi: 10.1016/0012-1606(75)90022-6.

引用本文的文献

1
Histofluorescence of monoamines in newt forelimb regenerates.蝾螈前肢再生中单胺类物质的组织荧光
Wilehm Roux Arch Dev Biol. 1978 Mar;185(1):79-94. doi: 10.1007/BF00848216.
2
Promotion of mitosis in cultured newt limb regenerates by a diffusible nerve factor.一种可扩散神经因子对培养的蝾螈肢体再生中细胞有丝分裂的促进作用。
In Vitro. 1981 Feb;17(2):167-72. doi: 10.1007/BF02618075.
3
Effects of forelimb amputation and denervation on protein synthesis in spinal cord ganglia of the newt.前肢截肢和去神经支配对蝾螈脊髓神经节中蛋白质合成的影响。
Proc Natl Acad Sci U S A. 1986 Oct;83(20):7971-4. doi: 10.1073/pnas.83.20.7971.