二甲基亚砜诱导HL60细胞分化过程中5-脂氧合酶基因的表达

5-Lipoxygenase gene expression in HL60 cells during differentiation with DMSO.

作者信息

Piechele G, Colli S, Tremoli E, Maggi A

机构信息

Institute of Pharmacological Sciences, University of Milan, Italy.

出版信息

Pharmacol Res. 1993 Jan-Feb;27(1):53-60. doi: 10.1006/phrs.1993.1005.

DOI:10.1006/phrs.1993.1005

PMID:8456058

Abstract

The model of promyelocytic leukemia cells HL60 was utilized to study the accumulation of 5-lipoxygenase mRNA during the cellular differentiation induced by DMSO. In the present study a strict correlation between the increase in state of differentiation of HL60 and accumulation of 5-lipoxygenase mRNA is demonstrated, indicating that HL60 cells are an interesting model for the study of drugs which could interfere with the synthesis of the enzyme.

摘要

利用早幼粒细胞白血病细胞HL60模型研究二甲基亚砜诱导细胞分化过程中5-脂氧合酶mRNA的积累。在本研究中，HL60细胞分化状态的增加与5-脂氧合酶mRNA的积累之间存在严格的相关性，这表明HL60细胞是研究可能干扰该酶合成的药物的一个有趣模型。