Ponton A, Thirion J P, Sirois P
Department of Pharmacology, Faculty of Medicine, University of Sherbrooke, P.Q., Canada.
Prostaglandins. 1997 Jan;53(1):49-58. doi: 10.1016/s0090-6980(96)00140-2.
This paper reports on the involvement of c-MYB in the regulation of 5-lipoxygenase gene expression during differentiation of human HL-60 cells. We demonstrate that c-MYB binds the 5-lipoxygenase promoter in undifferentiated cells but not in DMSO-differentiated cells. Also, we show that overexpression of c-myb cDNA in differentiated HL-60 cells represses the 5-lipoxygenase gene expression.
