Saindon P J, Cauchon N S, Sutton P A, Chang C J, Peck G E, Byrn S R
Department of Medicinal Chemistry, Purdue University, West Lafayette, Indiana 47907.
Pharm Res. 1993 Feb;10(2):197-203. doi: 10.1023/a:1018922407786.
Solid-state 13C NMR spectra of tablets or capsules of prednisolone, enalapril maleate, lovastatin, simvastatin, ibuprofen, flurbiprofen, mefenamic acid, indomethacin, diflunisal, sulindac, and piroxicam were obtained in the CP/MAS mode at 50 MHz. These studies show that (1) solid-state NMR spectroscopy can detect the active ingredients in low-dose tablets and capsules; (2) the use of interrupted decoupling often results in suppression of resonances due to excipients, thereby allowing better detection of resonances from the drug; and (3) the technique permits discrimination between two prednisolone polymorphs present in tablets obtained from various manufacturers even though the tablets contain only approximately 5% (w/w) of the drug.
在50兆赫的CP/MAS模式下，获得了泼尼松龙、马来酸依那普利、洛伐他汀、辛伐他汀、布洛芬、氟比洛芬、甲芬那酸、吲哚美辛、二氟尼柳、舒林酸和吡罗昔康片剂或胶囊的固态13C核磁共振谱。这些研究表明：（1）固态核磁共振光谱法可检测低剂量片剂和胶囊中的活性成分；（2）使用间断去耦常常会抑制辅料产生的共振，从而能更好地检测药物产生的共振；（3）即使片剂中药物含量仅约5%（w/w），该技术也能区分不同厂家生产的片剂中存在的两种泼尼松龙多晶型物。
