Hashimoto I
J Neurosurg. 1977 Apr;46(4):419-27. doi: 10.3171/jns.1977.46.4.0419.
The author reports a family in which four members had intracranial aneurysms and one additional member was suspect. One member had multiple aneurysms that were successfully treated surgically. Elective angiography on five asymptomatic members of the family disclosed asymptomatic aneurysms in two. In addition, cerebrovascular anomalies were found in many of the family members. The parents of the family were consanguineous. High incidence of these associated anomalies and consanguinity in the parents tend to suggest the hereditary basis of the disease. Banding analysis of chromosomes in three siblings with aneurysms and three siblings without aneurysms was carried out. Elective investigation of the asymptomatic members should be considered where there are already two or more affected in a family. The indications for surgical prophylaxis on asymptomatic aneurysms in other members of the family are discussed.
作者报告了一个家族，其中四名成员患有颅内动脉瘤，另有一名成员疑似患病。一名成员有多个动脉瘤，经手术成功治疗。对该家族五名无症状成员进行的选择性血管造影显示，其中两人有无症状动脉瘤。此外，在许多家族成员中发现了脑血管异常。该家族的父母是近亲结婚。这些相关异常的高发病率以及父母的近亲关系倾向于表明该疾病的遗传基础。对三名患有动脉瘤的兄弟姐妹和三名没有动脉瘤的兄弟姐妹进行了染色体带型分析。如果一个家族中已经有两名或更多患者，应考虑对无症状成员进行选择性检查。讨论了对家族其他成员无症状动脉瘤进行手术预防的指征。
