Sandoval M R, Dorce V A
Pharmacology Laboratory, Butantan Institute, São Paulo, Brazil.
Toxicon. 1993 Feb;31(2):205-12. doi: 10.1016/0041-0101(93)90287-s.
This study was designed to investigate the convulsant effects of T. serrulatus scorpion venom in rats. Pretreatment of rats with venom increased the minimum convulsant dose of picrotoxin, impaired convulsion generalization and displaced to the left the dose-response curve for picrotoxin. It also decreased the intensity but prolonged the duration of seizures caused by pentylenetetrazol injection. Microinjection of the venom into the dorsal hippocampus induced behavioural alterations and epileptiform waves in the EEG. Venom also altered the threshold for, and intensity of, convulsions induced in different experimental models of epilepsy. Different fractions of the venom may be responsible for these different effects. Therefore, purification of venom toxins is necessary for the complete understanding of the present results.
本研究旨在探讨锯齿蝎毒对大鼠的惊厥作用。用蝎毒预处理大鼠可提高印防己毒素的最小惊厥剂量，损害惊厥的泛化，并使印防己毒素的剂量-反应曲线向左移位。它还降低了由戊四氮注射引起的癫痫发作强度，但延长了发作持续时间。将蝎毒微量注射到背侧海马体可诱发行为改变和脑电图中的癫痫样波。蝎毒还改变了不同癫痫实验模型中惊厥的阈值和强度。蝎毒的不同组分可能是这些不同作用的原因。因此，为了全面理解目前的结果，有必要对蝎毒毒素进行纯化。
