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染色体分布、分子马达与清晰蛋白

Chromosome distribution, molecular motors and the claret protein.

作者信息

Endow S A

机构信息

Department of Microbiology, Duke University Medical Center, Durham, NC 27710.

出版信息

Trends Genet. 1993 Feb;9(2):52-5. doi: 10.1016/0168-9525(93)90187-M.

DOI:10.1016/0168-9525(93)90187-M
PMID:8456502
Abstract

Recently, proteins have been identified that are required for proper distribution of chromosomes in meiosis and mitosis. Unexpectedly, several of these are microtubule motor proteins. This finding has prompted further investigation into the basis of meiotic and mitotic chromosome movement. The claret protein, or ncd, is one of the new motor proteins that may perform several functions in meiosis and early mitosis in Drosophila.

摘要

最近,已鉴定出在减数分裂和有丝分裂中染色体正确分布所必需的蛋白质。出乎意料的是,其中有几种是微管运动蛋白。这一发现促使人们进一步研究减数分裂和有丝分裂染色体运动的基础。暗红色蛋白(ncd)是一种新的运动蛋白,可能在果蝇的减数分裂和早期有丝分裂中发挥多种功能。

相似文献

1
Chromosome distribution, molecular motors and the claret protein.染色体分布、分子马达与清晰蛋白
Trends Genet. 1993 Feb;9(2):52-5. doi: 10.1016/0168-9525(93)90187-M.
2
Mutants of the microtubule motor protein, nonclaret disjunctional, affect spindle structure and chromosome movement in meiosis and mitosis.微管运动蛋白“非红粒不分离”的突变体影响减数分裂和有丝分裂中的纺锤体结构及染色体运动。
J Cell Sci. 1992 Mar;101 ( Pt 3):547-59. doi: 10.1242/jcs.101.3.547.
3
The Drosophila ncd microtubule motor protein is spindle-associated in meiotic and mitotic cells.果蝇ncd微管运动蛋白在减数分裂和有丝分裂细胞中与纺锤体相关。
J Cell Sci. 1992 Dec;103 ( Pt 4):1013-20. doi: 10.1242/jcs.103.4.1013.
4
Mutants of the Drosophila ncd microtubule motor protein cause centrosomal and spindle pole defects in mitosis.果蝇ncd微管运动蛋白的突变体在有丝分裂过程中会导致中心体和纺锤极缺陷。
J Cell Sci. 1994 Apr;107 ( Pt 4):859-67. doi: 10.1242/jcs.107.4.859.
5
Centrosome and spindle function of the Drosophila Ncd microtubule motor visualized in live embryos using Ncd-GFP fusion proteins.利用Ncd-GFP融合蛋白在活胚胎中观察果蝇Ncd微管马达的中心体和纺锤体功能。
J Cell Sci. 1996 Oct;109 ( Pt 10):2429-42. doi: 10.1242/jcs.109.10.2429.
6
subito encodes a kinesin-like protein required for meiotic spindle pole formation in Drosophila melanogaster.subito基因编码一种在黑腹果蝇减数分裂纺锤体极形成过程中所需的类驱动蛋白。
Genetics. 2002 Apr;160(4):1489-501. doi: 10.1093/genetics/160.4.1489.
7
Separation of meiotic and mitotic effects of claret non-disjunctional on chromosome segregation in Drosophila.果蝇中紫红色不分离基因对减数分裂和有丝分裂时染色体分离作用的分离
EMBO J. 1991 Feb;10(2):419-24. doi: 10.1002/j.1460-2075.1991.tb07963.x.
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Spindle dynamics during meiosis in Drosophila oocytes.果蝇卵母细胞减数分裂过程中的纺锤体动力学。
J Cell Biol. 1997 Jun 16;137(6):1321-36. doi: 10.1083/jcb.137.6.1321.
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Mediation of meiotic and early mitotic chromosome segregation in Drosophila by a protein related to kinesin.一种与驱动蛋白相关的蛋白质介导果蝇减数分裂和早期有丝分裂染色体分离。
Nature. 1990 May 3;345(6270):81-3. doi: 10.1038/345081a0.
10
Assembly pathway of the anastral Drosophila oocyte meiosis I spindle.无星果蝇卵母细胞减数分裂I纺锤体的组装途径。
J Cell Sci. 2005 Apr 15;118(Pt 8):1745-55. doi: 10.1242/jcs.02304. Epub 2005 Mar 29.

引用本文的文献

1
Genetic and molecular analysis of wings apart-like (wapl), a gene controlling heterochromatin organization in Drosophila melanogaster.翅裂样基因(wapl)的遗传与分子分析,wapl是一种控制黑腹果蝇异染色质组织的基因。
Genetics. 2000 Apr;154(4):1693-710. doi: 10.1093/genetics/154.4.1693.
2
Opposing motor activities are required for the organization of the mammalian mitotic spindle pole.哺乳动物有丝分裂纺锤体极的组织需要相反的运动活动。
J Cell Biol. 1996 Oct;135(2):399-414. doi: 10.1083/jcb.135.2.399.
3
Going mobile: microtubule motors and chromosome segregation.
走向移动:微管马达与染色体分离
Proc Natl Acad Sci U S A. 1996 Mar 5;93(5):1735-42. doi: 10.1073/pnas.93.5.1735.
4
Kinesin-related proteins in the mammalian testes: candidate motors for meiosis and morphogenesis.哺乳动物睾丸中的驱动蛋白相关蛋白:减数分裂和形态发生的候选驱动蛋白
Mol Biol Cell. 1996 Feb;7(2):289-305. doi: 10.1091/mbc.7.2.289.
5
The radial positions of metaphase chromosomes may be a consequence of the relative strength of their interaction with the spindle and their size.
Chromosome Res. 1994 Jan;2(1):21-4. doi: 10.1007/BF01539449.
6
Identification and partial characterization of mitotic centromere-associated kinesin, a kinesin-related protein that associates with centromeres during mitosis.有丝分裂着丝粒相关驱动蛋白的鉴定与部分特性分析,一种在有丝分裂期间与着丝粒相关的驱动蛋白相关蛋白。
J Cell Biol. 1995 Jan;128(1-2):95-104. doi: 10.1083/jcb.128.1.95.
7
Horka, a dominant mutation of Drosophila, induces nondisjunction and, through paternal effect, chromosome loss and genetic mosaics.霍尔卡(Horka)是果蝇的一种显性突变,会诱导不分离现象,并通过父本效应导致染色体丢失和遗传嵌合体。
Genetics. 1995 Apr;139(4):1585-99. doi: 10.1093/genetics/139.4.1585.