Ratcliffe A, Rosenwasser M P, Mahmud F, Glazer P A, Saed-Nejad F, Lane N, Mow V C
Department of Orthopaedic Surgery, Columbia University, New York, NY 10032.
Agents Actions Suppl. 1993;39:207-11. doi: 10.1007/978-3-0348-7442-7_23.
A canine experimental model of osteoarthritis (OA), generated by arthroscopic transection of the anterior cruciate ligament (ACL) of the knee, was used to investigate the in vivo effects of the NSAID naproxen on the course of cartilage degeneration. The drug was given at the time of surgery, or from before surgery, and for 16 weeks after surgery. Analysis of the articular cartilage showed the naproxen was able to significantly suppress the decrease in proteoglycan content and metalloproteinase activities. The results indicate that pharmaceutical agents have the potential to modulate the progression of degenerative joint disease.
通过关节镜切断犬膝关节前交叉韧带（ACL）建立骨关节炎（OA）犬实验模型，用于研究非甾体抗炎药萘普生对软骨退变进程的体内影响。该药物在手术时给药，或在手术前开始给药，并在术后持续给药16周。关节软骨分析表明，萘普生能够显著抑制蛋白聚糖含量的降低和金属蛋白酶活性。结果表明，药物制剂有调节退行性关节疾病进展的潜力。
