亚硒酸盐和硒代蛋氨酸对大鼠谷胱甘肽过氧化物酶的影响。
Effects of selenite and selenomethionine on glutathione peroxidase in the rat.
作者信息
Pierce S, Tappel A L
出版信息
J Nutr. 1977 Mar;107(3):475-9. doi: 10.1093/jn/107.3.475.
PMID:845684
Abstract
The activity of glutathione (GSH) peroxidase (EC 1.11.1.9) decreased in tissues of rats fed a diet deficient in selenium. A single dose of 300 mug selenium by stomach tube increased GSH peroxidase activity within 48 hours. The effects of selenite and selenomethionine on GSH peroxidase activity were roughly similar. This study provides evidence that selenium from both selenite and selenomethionine is readily available for synthesis of the selenoenzyme GSH peroxidase in rat tissues.
摘要
喂食缺硒饮食的大鼠组织中谷胱甘肽（GSH）过氧化物酶（EC 1.11.1.9）的活性降低。经胃管单次给予300微克硒可在48小时内提高GSH过氧化物酶的活性。亚硒酸盐和硒代蛋氨酸对GSH过氧化物酶活性的影响大致相似。本研究提供了证据，表明亚硒酸盐和硒代蛋氨酸中的硒均可在大鼠组织中轻易用于合成含硒酶GSH过氧化物酶。
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