Donnenfeld A E, Pulkkinen A, Palomaki G E, Knight G J, Haddow J E
Department of Obstetrics and Gynecology, Pennsylvania Hospital, Philadelphia 19107.
Am J Obstet Gynecol. 1993 Mar;168(3 Pt 1):781-2. doi: 10.1016/s0002-9378(12)90818-2.
Our purpose was to determine the simultaneous concentrations of serum cotinine in both fetal and maternal blood.
Serum cotinine levels were measured in 11 maternal-fetal pairs at percutaneous umbilical blood sampling. Statistical analysis was performed by means of a one-group t test to determine whether the ratio of fetal-to-maternal cotinine was significantly different from 1.
Fetal cotinine levels ranged from 75% to 110% of maternal values (mean ratio 0.90, 95% confidence interval 0.83 to 0.97). Fetal levels were significantly lower than maternal concentrations (p = 0.02).
Cotinine, a metabolite of nicotine used to quantify exposure to tobacco smoke, readily gains access to the fetal circulation. Fetal cotinine concentrations in pregnant women smokers are, on average, 90% of maternal values throughout gestation.
我们的目的是测定胎儿和母体血液中血清可替宁的同时浓度。
在经皮脐血采样时，对11对母婴的血清可替宁水平进行了测量。通过单组t检验进行统计分析，以确定胎儿与母体可替宁的比率是否显著不同于1。
胎儿可替宁水平为母体值的75%至110%（平均比率0.90，95%置信区间0.83至0.97）。胎儿水平显著低于母体浓度（p = 0.02）。
可替宁是用于量化接触烟草烟雾的尼古丁代谢产物，很容易进入胎儿循环。在整个孕期，吸烟孕妇的胎儿可替宁浓度平均为母体值的90%。
