TDx FLM检测在胎儿肺成熟度中的作用。

Role of the TDx FLM assay in fetal lung maturity.

作者信息

Herbert W N, Chapman J F, Schnoor M M

机构信息

Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill.

出版信息

Am J Obstet Gynecol. 1993 Mar;168(3 Pt 1):808-12. doi: 10.1016/s0002-9378(12)90825-x.

DOI:10.1016/s0002-9378(12)90825-x

PMID:8456885

Abstract

OBJECTIVE

We evaluated the usefulness of the recently introduced TDx FLM assay in determining fetal lung maturity.

STUDY DESIGN

The TDx FLM assay was compared with the lecithin/sphingomyelin ratio, the foam stability index, and the presence of phosphatidylglycerol in amniotic fluid samples from 102 pregnancies, among which respiratory distress syndrome developed in 22 infants.

RESULTS

The TDx FLM assay met or exceeded results of other tests with respect to sensitivity (100% vs 86% to 100%), specificity (82% vs 38% to 78%), predictive value of a mature test result (100% vs 95% to 100%), predictive value of an immature test result (61% vs 31% to 51%), and efficiency (86% vs 51% to 79%). In a sequential testing strategy the TDx FLM assay performed well as the initial test. Our data indicate that the value for maturity suggested by the manufacturer may be more conservative than necessary.

CONCLUSIONS

The TDx FLM assay appears to be a useful test in the field of fetal lung maturity testing.

摘要

目的

我们评估了最近推出的TDx FLM检测法在确定胎儿肺成熟度方面的实用性。

研究设计

将TDx FLM检测法与来自102例妊娠的羊水样本中的卵磷脂/鞘磷脂比值、泡沫稳定性指数以及磷脂酰甘油的存在情况进行比较，其中22例婴儿发生了呼吸窘迫综合征。

结果

在敏感性（100%对86%至100%）、特异性（82%对38%至78%）、成熟检测结果的预测值（100%对95%至100%）、未成熟检测结果的预测值（61%对31%至51%）以及效率（86%对51%至79%）方面，TDx FLM检测法达到或超过了其他检测方法的结果。在序贯检测策略中，TDx FLM检测法作为初始检测表现良好。我们的数据表明，制造商建议的成熟度值可能比必要的更为保守。