Steinfeld J D, Samuels P, Bulley M A, Cohen A W, Goodman D B, Senior M B
Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia.
Obstet Gynecol. 1992 Mar;79(3):460-4. doi: 10.1097/00006250-199203000-00027.
Accurate assessment of fetal lung maturity is essential in the management of high-risk obstetric patients. New rapid techniques have been developed to supplement time-consuming chromatographic methods. We compared one of these newer methods, the TDx-FLM, to the standard tests for fetal pulmonary maturity. There was an excellent correlation between the TDx and the lecithin-sphingomyelin ratio (r = 0.78). Although a TDx value of 70 or greater is considered mature, we found a value of 50 or greater predictive of fetal lung maturity in 100% of cases, and have chosen to redefine a mature value as 50 or greater in our institution. This value has greatly enhanced the clinical applicability of the test, allowing use of a large number of specimens from the previously poorly understood and often disregarded borderline category.
准确评估胎儿肺成熟度对于高危产科患者的管理至关重要。已开发出新的快速技术来补充耗时的色谱法。我们将其中一种较新的方法TDx-FLM与胎儿肺成熟度的标准测试进行了比较。TDx与卵磷脂-鞘磷脂比值之间存在极好的相关性（r = 0.78）。虽然TDx值70或更高被认为是成熟的，但我们发现50或更高的值在100%的病例中可预测胎儿肺成熟度，并且我们机构已选择将成熟值重新定义为50或更高。该值极大地提高了该测试的临床适用性，使得能够使用大量来自之前了解甚少且常被忽视的临界类别样本。
