Fortunato S J, Welt S I, Stewart J T
Department of Obstetrics and Gynecology, Tulane University, School of Medicine, New Orleans, LA 70112.
Am J Obstet Gynecol. 1993 Mar;168(3 Pt 1):914-5. doi: 10.1016/s0002-9378(12)90844-3.
Ceftizoxime concentrations are higher in cord blood and amniotic fluid than in maternal blood. More avid binding to fetal serum proteins is a suggested mechanism. We measured ceftizoxime protein binding in fetal and maternal blood and documented significantly less protein binding to fetal proteins (21.9% vs 57.8%).
头孢唑肟在脐血和羊水中的浓度高于母体血液中的浓度。一种推测的机制是其与胎儿血清蛋白的结合更紧密。我们测量了胎儿和母体血液中头孢唑肟的蛋白结合情况，结果表明其与胎儿蛋白的结合明显较少（分别为21.9%和57.8%）。
