Differential protein binding of ceftizoxime in cord versus maternal serum.
作者信息
Fortunato S J, Welt S I, Stewart J T
机构信息
Department of Obstetrics and Gynecology, Tulane University, School of Medicine, New Orleans, LA 70112.
出版信息
Am J Obstet Gynecol. 1993 Mar;168(3 Pt 1):914-5. doi: 10.1016/s0002-9378(12)90844-3.
PMID:8456901
Abstract
Ceftizoxime concentrations are higher in cord blood and amniotic fluid than in maternal blood. More avid binding to fetal serum proteins is a suggested mechanism. We measured ceftizoxime protein binding in fetal and maternal blood and documented significantly less protein binding to fetal proteins (21.9% vs 57.8%).
摘要
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