浸润性宫颈癌患者血清鳞状细胞癌抗原水平：反应及复发的预测

Serum squamous cell carcinoma antigen levels in invasive cervical cancer: prediction of response and recurrence.

作者信息

Rose P G, Baker S, Fournier L, Nelson B E, Hunter R E

机构信息

Department of Obstetrics and Gynecology, University of Massachusetts Medical School, Worcester.

出版信息

Am J Obstet Gynecol. 1993 Mar;168(3 Pt 1):942-6. doi: 10.1016/s0002-9378(12)90850-9.

DOI:10.1016/s0002-9378(12)90850-9

PMID:8456907

Abstract

OBJECTIVE

The rate of normalization of human chorionic gonadotropin or CA 125 in other gynecologic malignancies is highly predictive of response to therapy and recurrence. Serum squamous cell carcinoma antigen (SCC antigen) levels were studied in patients with invasive cervical carcinoma to determine if the rate of normalization was associated with outcome.

STUDY DESIGN

One hundred eighty-four patients were studied. A logistic regression of elevated SCC antigen levels was performed.

RESULTS

In primary squamous cell carcinoma the SCC antigen level was elevated in stages I, II, III, and IV disease and all stages combined in 24%, 57%, 67%, 71%, and 43% of cases, respectively. Only 27% of patients with nonsquamous carcinoma of the cervix had elevated SCC antigen levels. SCC antigen levels were elevated in 50% of patients with recurrent disease. In both primary and recurrent disease elevated SCC antigen levels decreased with effective therapy. Normalization of elevated SCC levels was associated with a complete response; however, logistic regression of SCC antigen values was not.

CONCLUSION

When initially elevated, SCC antigen assays aided in determination of response and detection of recurrences.

摘要

目的

人绒毛膜促性腺激素或CA 125在其他妇科恶性肿瘤中的正常化率对治疗反应和复发具有高度预测性。对浸润性宫颈癌患者的血清鳞状细胞癌抗原（SCC抗原）水平进行了研究，以确定其正常化率是否与预后相关。

研究设计

对184例患者进行了研究。对升高的SCC抗原水平进行了逻辑回归分析。

结果

在原发性鳞状细胞癌中，I期、II期、III期和IV期疾病以及所有阶段合并时，SCC抗原水平升高的病例分别为24%、57%、67%、71%和43%。宫颈非鳞状细胞癌患者中只有27%的SCC抗原水平升高。50%的复发疾病患者SCC抗原水平升高。在原发性和复发性疾病中，有效的治疗可使升高的SCC抗原水平降低。SCC水平的正常化与完全缓解相关；然而，SCC抗原值的逻辑回归分析并非如此。