Zile M, Bunge C, Deluca H F
J Nutr. 1977 Apr;107(4):552-60. doi: 10.1093/jn/107.4.552.
Cell division kinetics and the biochemical composition of the small intestine of normal and mildly vitamin A-deficient rats have been examined. Thymidine labeling index, growth fraction and the content of DNA, RNA and protein in the jejunal mucosa were not significantly affected by vitamin A deficiency. On the other hand, the duration of the cell cycle of jejunal crypt cells was found to be lengthened by vitamin A deficiency and this increase in generation time was due mainly to a lengthening of the DNA synthesis phase. Furthermore, the labeling pattern of the newly divided crypt cells of the vitamin A-deficient rats was strikingly different from that of the vitamin A-supplemented rats, suggesting an impaired migration of cells out of the crypts. These findings suggest that vitamin A may play a role in the regulation of cell division in the small intestine of the rat.
已对正常和轻度维生素A缺乏大鼠小肠的细胞分裂动力学和生化组成进行了研究。维生素A缺乏对空肠黏膜中的胸苷标记指数、生长分数以及DNA、RNA和蛋白质含量没有显著影响。另一方面，发现维生素A缺乏会延长空肠隐窝细胞的细胞周期持续时间，而这种增殖时间的增加主要是由于DNA合成期延长所致。此外，维生素A缺乏大鼠新分裂的隐窝细胞的标记模式与补充维生素A的大鼠明显不同，这表明细胞从隐窝中迁移受损。这些发现表明，维生素A可能在大鼠小肠细胞分裂的调节中起作用。
