Zile M H, Bunge E C, DeLuca H F
J Nutr. 1979 Oct;109(10):1787-96. doi: 10.1093/jn/109.10.1787.
The influence of vitamin A depletion on tissue composition was studied in rats that were marginally vitamin A deficient, i.e. at their weight plateau stage. The total number of cells (DNA) was decreased in most organs as a result of vitamin A depletion. In thymus, spleen and the sublingual glands there was also a dramatic reduction in the number of cells per gram of tissue and in thymus and sublingual glands there was an increase in the protein to DNA ratio as a result of absence of dietary.vitamin A. We present the hypothesis that vitamin A stimulates growth by a direct role in cell replication in addition to or instead of stimulating the differentiation of epithelial and bone cells.
在处于维生素A边缘性缺乏状态（即体重处于平稳阶段）的大鼠中，研究了维生素A缺乏对组织组成的影响。由于维生素A缺乏，大多数器官中的细胞总数（DNA）减少。在胸腺、脾脏和舌下腺中，每克组织中的细胞数量也显著减少，并且由于缺乏膳食维生素A，胸腺和舌下腺中的蛋白质与DNA的比率增加。我们提出这样一个假说：维生素A除了刺激上皮细胞和骨细胞的分化，或取而代之，通过在细胞复制中直接发挥作用来刺激生长。
