衰老过程中Wistar和Fischer 344大鼠品系的体内脑血管反应性
In vivo cerebrovascular reactivity in Wistar and Fischer 344 rat strains during aging.
作者信息
Lartaud I, Bray-des-Boscs L, Chillon J M, Atkinson J, Capdeville-Atkinson C
机构信息
Laboratoire de Pharmacologie Cardio-vasculaire, Faculté de Pharmacie, Université de Nancy I, France.
出版信息
Am J Physiol. 1993 Mar;264(3 Pt 2):H851-8. doi: 10.1152/ajpheart.1993.264.3.H851.
Basal cerebral blood flow (CBF) and CBF regulation after hypercapnia and hypotensive hemorrhage were investigated using H2 clearance in the frontal cortex of awake 2-, 14-, or 23-mo-old Wistar or Fischer 344 rats. Basal CBF decreased in old Wistar but not in mature Wistar (old 64.4 +/- 2.8, mature 87.6 +/- 2.6, young 79.6 +/- 2.2 ml.min-1 x 100 g-1) or in old Fischer 344 (old 71.9 +/- 2.9, young 73.3 +/- 1.6 ml.min-1 x 100 g-1) rats. Cerebrovascular reactivity to hypercapnia decreased in mature and old Wistar (old 2.1 +/- 0.3, mature 3.1 +/- 0.7, young 7.0 +/- 2.1 ml.min-1 x 100 g-1 x mmHg-1) but not in old Fischer 344 rats (old 4.6 +/- 1.4, young 4.9 +/- 0.9 ml.min-1 x 100 g-1 x mmHg-1). The lower limit of CBF autoregulation increased by 20 mmHg during maturation and/or aging in the two strains. Because blood gases and pH evolved similarly in both strains, we postulate that differences in cerebrovascular structure and/or function explain the differences in CBF regulation in the older representatives of the two strains.
采用氢清除法，对2月龄、14月龄或23月龄清醒的Wistar大鼠或Fischer 344大鼠额叶皮质的脑基底血流量（CBF）以及高碳酸血症和低血压性出血后的CBF调节进行了研究。老年Wistar大鼠的基底CBF降低，但成年Wistar大鼠（老年64.4±2.8，成年87.6±2.6，幼年79.6±2.2 ml·min⁻¹×100 g⁻¹）或老年Fischer 344大鼠（老年71.9±2.9，幼年73.3±1.6 ml·min⁻¹×100 g⁻¹）未降低。成年和老年Wistar大鼠对高碳酸血症的脑血管反应性降低（老年2.1±0.3，成年3.1±0.7，幼年7.0±2.1 ml·min⁻¹×100 g⁻¹×mmHg⁻¹），但老年Fischer 344大鼠未降低（老年4.6±1.4，幼年4.9±0.9 ml·min⁻¹×100 g⁻¹×mmHg⁻¹）。在两个品系的成熟和/或衰老过程中，CBF自动调节的下限升高了20 mmHg。由于两个品系的血气和pH变化相似，我们推测脑血管结构和/或功能的差异解释了两个品系老年代表动物在CBF调节方面的差异。
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