免疫反应中与应变相关的差异：与人类中风的相关性。
Strain-Related Differences in the Immune Response: Relevance to Human Stroke.
作者信息
Becker Kyra J
机构信息
Department of Neurology, University of Washington School of Medicine, Harborview Medical Center, 325 9th Ave, Box 359775, Seattle, WA, 98104-2499, USA.
出版信息
Transl Stroke Res. 2016 Aug;7(4):303-12. doi: 10.1007/s12975-016-0455-9. Epub 2016 Feb 10.
Abstract
There are significant differences in the immune response and in the susceptibility to autoimmune diseases among rodent strains. It would thus be expected that the contribution of the immune response to cerebral ischemic injury would also differ among rodent strains. More importantly, there are significant differences between the immune responses of rodents and humans. All of these factors are likely to impact the successful translation of immunomodulatory therapies from experimental rodent models to patients with stroke.
摘要
啮齿动物品系之间在免疫反应和自身免疫性疾病易感性方面存在显著差异。因此，可以预期免疫反应对脑缺血损伤的影响在啮齿动物品系之间也会有所不同。更重要的是，啮齿动物和人类的免疫反应之间存在显著差异。所有这些因素都可能影响免疫调节疗法从实验性啮齿动物模型成功转化至中风患者。
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