Zeman F J, Fratzke M
J Nutr. 1977 Apr;107(4):690-9. doi: 10.1093/jn/107.4.690.
The absorption of 3-O-methylglucose (TMG) and of lactose has been studied in the young of female rats fed a protein-deficient diet during pregnancy. Postnatally, these young were suckled by stock diet-fed dams. Intestines of newborn, 4-day and 12-day old pups were infused in situ with 5% TMG or 3.5% lactose. The mean amount retained per enterocyte was measured as well as the mean amount absorbed from the lumen and transferred from the enterocyte. Absorption of lactose was reduced in the enterocytes of newborn prenatally protein-deprived (PPD) young but not postnatally, while TMG absorption was normal at birth and 12 days but reduced at 4 days. The amount of carbohydrates absorbed in total or per unit intestinal weight seemed to vary with changes in the number of absorptive cells. It is suggested that reduced absorption in PPD pups is primarily related to the smaller number of absorptive cells in these young. There is a greater increase in numbers of cells and in absorption per cell between birth and 12 days in PPD young than in controls, indicating that the effect on the intestine of prenatal protein deprived young is at least partially reversible.
对孕期喂食蛋白质缺乏饮食的雌性大鼠幼崽的3 - O - 甲基葡萄糖（TMG）和乳糖吸收情况进行了研究。出生后，这些幼崽由喂食标准饮食的母鼠哺乳。对新生、4日龄和12日龄幼崽的肠道进行原位灌注5%的TMG或3.5%的乳糖。测量了每个肠细胞保留的平均量以及从肠腔吸收并从肠细胞转运的平均量。产前蛋白质缺乏（PPD）的新生幼崽肠细胞中乳糖的吸收减少，但产后未减少，而TMG吸收在出生时和12天时正常，但在4天时减少。总吸收或每单位肠道重量吸收的碳水化合物量似乎随吸收细胞数量的变化而变化。提示PPD幼崽吸收减少主要与这些幼崽中吸收细胞数量较少有关。与对照组相比，PPD幼崽在出生至12天期间细胞数量和每个细胞吸收的增加幅度更大，这表明产前蛋白质缺乏幼崽对肠道的影响至少部分是可逆的。
