McCullagh P
John Curtin School of Medical Research, Australian National University, Canberra.
J Autoimmun. 1993 Feb;6(1):51-62. doi: 10.1006/jaut.1993.1005.
Previous experiments have shown that surgical removal of the thyroid gland from the foetal lamb one third of the way through gestation prevents the development of self tolerance towards thyroid-specific determinants. As a result, self thyroid tissue reintroduced into the foetal lamb after maturation of the immune system is not recognized as self and is subject to autoimmune thyroiditis. Furthermore, the transplantation of a thyroid allograft into a foetal lamb immediately after extirpation of its own gland has been shown not to direct the development of self tolerance to thyroid determinants. In the present experiment, foetal lambs were submitted to removal of the entire thyroid gland and the majority of the thymus gland, at 51-54 days of gestation followed by the immediate implantation of thyroid and thymic allografts. The additional implantation of thymus tissue did not affect the previously observed incapacity of a thyroid allograft to facilitate induction of organ-specific tolerance by the thyroid allograft. It was inferred that any T lymphocytes generated within the thymus graft and tolerant of thyroid-specific determinants had not had the capacity to suppress the activity of autoreactive cells generated in the host's thymus.
先前的实验表明，在妊娠三分之一阶段从胎羊身上手术切除甲状腺，会阻止对甲状腺特异性决定簇产生自身耐受性。结果，免疫系统成熟后重新植入胎羊体内的自身甲状腺组织不被识别为自身组织，并会引发自身免疫性甲状腺炎。此外，在切除自身甲状腺后立即将甲状腺同种异体移植到胎羊体内，已证明这不会引导对甲状腺决定簇产生自身耐受性。在本实验中，在妊娠51 - 54天时，将胎羊的整个甲状腺和大部分胸腺切除，随后立即植入甲状腺和胸腺同种异体移植物。额外植入胸腺组织并未影响先前观察到的甲状腺同种异体移植无法促进甲状腺同种异体移植诱导器官特异性耐受性的情况。据推测，在胸腺移植物内产生的、对甲状腺特异性决定簇具有耐受性的任何T淋巴细胞，都没有能力抑制宿主胸腺中产生的自身反应性细胞的活性。
