Ladas I D, Pavlopoulos G P, Kokolakis S N, Theodossiadis G P
Department of Ophthalmology, Athens University School of Medicine, Greece.
Br J Ophthalmol. 1993 Mar;77(3):136-8. doi: 10.1136/bjo.77.3.136.
Fifty four eyes of 54 patients undergoing Nd-YAG laser posterior capsulotomy were randomly assigned to pretreatment with either 125 mg of oral acetazolamide (group A) or placebo (group B). During the first 3 hours following capsulotomy, an intraocular pressure (IOP) rise of at least 10 mm Hg was recorded in eight of the 26 eyes of group B (30.8%) and in none of the 28 eyes of group A (p < 0.01). A rise of at least 5 mm Hg was recorded in 16/26 (61.5%) and 4/28 (14.3%) eyes respectively (p < 0.001). Three eyes of group B developed an IOP greater than 35 mm Hg. We found that pretreatment with a low dose of acetazolamide is highly effective in preventing IOP elevation following Nd-YAG laser posterior capsulotomy.
54例行Nd-YAG激光后囊切开术的患者的54只眼睛被随机分为两组,一组术前口服125毫克乙酰唑胺(A组),另一组口服安慰剂(B组)。在囊切开术后的最初3小时内,B组26只眼中有8只(30.8%)眼压至少升高了10毫米汞柱,而A组28只眼中无一例出现这种情况(p<0.01)。眼压至少升高5毫米汞柱的情况在两组眼中分别为16/26(61.5%)和4/28(14.3%)(p<0.001)。B组有3只眼眼压高于35毫米汞柱。我们发现,低剂量乙酰唑胺预处理对预防Nd-YAG激光后囊切开术后眼压升高非常有效。