Szabo E, Mulshine J
National Cancer Institute, Bethesda, Maryland.
Curr Opin Oncol. 1993 Mar;5(2):302-9. doi: 10.1097/00001622-199303000-00009.
Lung cancer continues to be a leading cause of preventable death, with an estimated 123,000 of the 143,000 lung cancer deaths in the United States in 1991 directly attributable to tobacco smoking. Given that mortality from this disease has not changed appreciably in the past two decades and despite continuing advances in cancer treatment, a new emphasis is being placed on prevention and early detection research through the identification of high-risk individuals and the definition of useful biomarkers. This review summarizes the status of these efforts over the past year.
肺癌仍然是可预防死亡的主要原因，据估计，1991年美国14.3万例肺癌死亡病例中，有12.3万例直接归因于吸烟。鉴于在过去二十年中，这种疾病的死亡率没有明显变化，而且尽管癌症治疗不断取得进展，但目前正通过识别高危个体和定义有用的生物标志物，将新的重点放在预防和早期检测研究上。本综述总结了过去一年这些工作的进展情况。
