Mori K
Department of Neuroscience, Osaka Bioscience Institute, Japan.
Microsc Res Tech. 1993 Feb 1;24(2):131-41. doi: 10.1002/jemt.1070240205.
How are the axonal projections of olfactory and vomeronasal receptor neurons to the olfactory bulb formed during development? How are the primary olfactory axonal connections functionally organized? With progress in molecular biological techniques and histochemical methods, it became possible to study cellular strategies and molecular mechanisms which guide the primary olfactory axons of the main and accessory olfactory systems to the target glomeruli in the bulb. In addition, new methodologies have begun to elucidate various subsets of the primary olfactory axons with distinctive central connections. The aim of the present paper is to review (1) the characteristic organization of the projection of the primary olfactory axons, (2) projection patterns of histochemically defined subsets of primary olfactory axons, and (3) information on molecules expressed by the surface membrane of the primary olfactory axons. This knowledge gives insight into the functional organization of the primary olfactory axon projection, which is indispensable for understanding signal processing in the olfactory system. This knowledge also underscores the notion that the primary olfactory axon projection provides an excellent model system in which to study axonal guidance and the formation of specific synaptic connections.
嗅觉和犁鼻器受体神经元向嗅球的轴突投射在发育过程中是如何形成的？初级嗅觉轴突连接在功能上是如何组织的？随着分子生物学技术和组织化学方法的进步，研究引导主嗅觉系统和副嗅觉系统的初级嗅觉轴突到达嗅球中靶glomeruli的细胞策略和分子机制成为可能。此外，新方法已开始阐明具有独特中枢连接的初级嗅觉轴突的各种亚群。本文的目的是综述：（1）初级嗅觉轴突投射的特征性组织；（2）组织化学定义的初级嗅觉轴突亚群的投射模式；以及（3）初级嗅觉轴突表面膜表达的分子信息。这些知识有助于深入了解初级嗅觉轴突投射的功能组织，这对于理解嗅觉系统中的信号处理是必不可少的。这些知识还强调了这样一种观点，即初级嗅觉轴突投射提供了一个极好的模型系统，可用于研究轴突导向和特定突触连接的形成。
