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Pharmacokinetic and biopharmaceutic profile of chlordiazepoxide HC1 in healthy subjects: single-dose studies by the intravenous, intramuscular, and oral routes.

作者信息

Boxenbaum H G, Geitner K A, Jack M L, Dixon W R, Spiegel H E, Symington J, Christian R, Moore J D, Weissman L, Kaplan S A

出版信息

J Pharmacokinet Biopharm. 1977 Feb;5(1):3-23. doi: 10.1007/BF01064806.

DOI:10.1007/BF01064806
PMID:845790
Abstract
摘要

相似文献

1
Pharmacokinetic and biopharmaceutic profile of chlordiazepoxide HC1 in healthy subjects: single-dose studies by the intravenous, intramuscular, and oral routes.
J Pharmacokinet Biopharm. 1977 Feb;5(1):3-23. doi: 10.1007/BF01064806.
2
Pharmacokinetic and biopharmaceutic profile of chlordiazepoxide HC1 in healthy subjects: multiple-dose oral administration.健康受试者中盐酸氯氮卓的药代动力学和生物药剂学特征：多剂量口服给药
J Pharmacokinet Biopharm. 1977 Feb;5(1):25-39. doi: 10.1007/BF01064807.
3
Absorption of oral and intramuscular chlordiazepoxide.
Eur J Clin Pharmacol. 1978 Jun 19;13(4):267-74. doi: 10.1007/BF00716362.
4
Slow absorption of intramuscular chlordiazepoxide.
N Engl J Med. 1974 Nov 21;291(21):1116-8. doi: 10.1056/NEJM197411212912107.
5
Absorption of oral intramuscular chlordiazepoxide by alcoholics.
Clin Pharmacol Ther. 1978 May;23(5):535-41. doi: 10.1002/cpt1978235535.
6
Clinical pharmacokinetics of chlordiazepoxide.氯氮䓬的临床药代动力学
Clin Pharmacokinet. 1978 Sep-Oct;3(5):381-94. doi: 10.2165/00003088-197803050-00004.
7
Intramuscular injections and bioavailability.
Am J Hosp Pharm. 1977 Sep;34(9):965-8.
8
Bioavailability of drugs administered intramuscularly.肌内注射给药的药物生物利用度。
Aust Fam Physician. 1977 Aug;6(8):925-34.
9
Biological half-life of chlordiazepoxide and its metabolite, demoxepam, in man.
J Pharm Sci. 1971 Oct;60(10):1500-3. doi: 10.1002/jps.2600601012.
10
Effect of oral and intramuscular routes of administration on serum chlordiazepoxide levels and the prediction of these levels from predrug fasting serum glucose concentrations.
Res Commun Chem Pathol Pharmacol. 1974 Aug;8(4):697-702.

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Prevalence of Patients Admitted to Intensive Care After Administration of Chlordiazepoxide in the Emergency Room.在急诊室给予氯氮䓬后入住重症监护病房的患者患病率。
Basic Clin Pharmacol Toxicol. 2025 Apr;136(4):e70018. doi: 10.1111/bcpt.70018.
2
Single-dose Toxicity of Guseonwangdo-go Glucose 5% Intravenous Injection in a Rat Model.古仙王道葡萄糖5%静脉注射液在大鼠模型中的单剂量毒性
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Clinical pharmacokinetics of chlordiazepoxide in patients with alcoholic hepatitis.

本文引用的文献

1
The formulation and testing of models.模型的构建与测试。
Ann N Y Acad Sci. 1963 May 10;108:182-94. doi: 10.1111/j.1749-6632.1963.tb13373.x.
2
The relation between the binding of sulfonamides to albumin and their antibacterial efficacy.磺胺类药物与白蛋白的结合与其抗菌效力之间的关系。
J Pharmacol Exp Ther. 1960 Jul;129:282-90.
3
Intracellular acidbase relations and intracellular buffers.细胞内酸碱关系与细胞内缓冲物质
Eur J Clin Pharmacol. 1981 Mar;19(4):279-85. doi: 10.1007/BF00562805.
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Comparative pharmacokinetics of benzodiazepines in dog and man.苯二氮䓬类药物在犬和人类体内的比较药代动力学。
J Pharmacokinet Biopharm. 1982 Aug;10(4):411-26. doi: 10.1007/BF01065172.
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Interspecies variation in liver weight, hepatic blood flow, and antipyrine intrinsic clearance: extrapolation of data to benzodiazepines and phenytoin.
J Pharmacokinet Biopharm. 1980 Apr;8(2):165-76. doi: 10.1007/BF01065191.
6
Theorems and implications of a model-independent elimination/distribution function decomposition of linear and some nonlinear drug dispositions. II. Clearance concepts applied to the evaluation of distribution kinetics.线性及某些非线性药物处置的模型无关消除/分布函数分解的定理及推论。II. 应用于分布动力学评估的清除概念。
J Pharmacokinet Biopharm. 1985 Aug;13(4):441-51. doi: 10.1007/BF01061479.
7
Negative power functions of time in pharmacokinetics and their implications.
J Pharmacokinet Biopharm. 1985 Jun;13(3):309-46. doi: 10.1007/BF01065658.
8
Theorems and implications of a model-independent elimination/distribution function decomposition of linear and some nonlinear drug dispositions. III. Peripheral bioavailability and distribution time concepts applied to the evaluation of distribution kinetics.线性及某些非线性药物处置的模型无关消除/分布函数分解的定理与推论。III. 应用于分布动力学评估的外周生物利用度和分布时间概念
J Pharmacokinet Biopharm. 1987 Jun;15(3):281-304. doi: 10.1007/BF01066323.
9
Relationships between CSF drug concentrations, receptor binding characteristics, and pharmacokinetic and pharmacodynamic properties of selected 1,4-substituted benzodiazepines.脑脊液药物浓度、受体结合特性与选定的1,4-取代苯二氮䓬类药物的药代动力学和药效学性质之间的关系。
Clin Pharmacokinet. 1987 Sep;13(3):179-90. doi: 10.2165/00003088-198713030-00003.
10
Chlordiazepoxide metabolite accumulation in liver disease.氯氮䓬代谢物在肝脏疾病中的蓄积
Med Toxicol Adverse Drug Exp. 1989 Jan-Feb;4(1):73-6. doi: 10.1007/BF03259904.
Ann N Y Acad Sci. 1961 Jun 17;92:539-46. doi: 10.1111/j.1749-6632.1961.tb45004.x.
4
Carbon dioxide and intracellular homeostasis.
Ann N Y Acad Sci. 1961 Jun 17;92:547-58. doi: 10.1111/j.1749-6632.1961.tb45005.x.
5
Calculation of intracellular pH from the distribution of 5,5-dimethyl-2,4-oxazolidinedione (DMO); application to skeletal muscle of the dog.根据5,5-二甲基-2,4-恶唑烷二酮（DMO）的分布计算细胞内pH值；应用于犬的骨骼肌
J Clin Invest. 1959 May;38(5):720-9. doi: 10.1172/JCI103852.
6
New method for calculating the intrinsic absorption rate of drugs.计算药物内在吸收速率的新方法。
J Pharm Sci. 1968 Jun;57(6):918-28. doi: 10.1002/jps.2600570602.
7
Concept of a volume of distribution and possible errors in evaluation of this parameter.分布容积的概念以及该参数评估中可能存在的误差。
J Pharm Sci. 1968 Jan;57(1):128-33. doi: 10.1002/jps.2600570125.
8
Shortcomings in pharmacokinetic analysis by conceiving the body to exhibit properties of a single compartment.将人体视为具有单室性质进行药代动力学分析时存在的缺点。
J Pharm Sci. 1968 Jan;57(1):117-23. doi: 10.1002/jps.2600570123.
9
Hepatic vascular bed.肝血管床
Physiol Rev. 1971 Jan;51(1):23-65. doi: 10.1152/physrev.1971.51.1.23.
10
Pharmacokinetic model for chlordiazepoxide--HCl in the dog.狗体内氯氮䓬盐酸盐的药代动力学模型。
J Pharm Sci. 1970 Nov;59(11):1569-74. doi: 10.1002/jps.2600591105.