Kjaer T B, Welling P G, Madsen P O
J Pharm Sci. 1977 Mar;66(3):345-7. doi: 10.1002/jps.2600660310.
Concentrations of ampicillin and the methoxymethyl ester of hetacillin were measured in plasma, prostatic fluid, and spinal fluid of dogs receiving ampicillin or the hetacillin ester by continuous intravenous infusion. The ratios of ampicillin in prostatic fluid relative to plasma levels were higher after dosing with the hetacillin ester. Pharmacokinetic parameter values were consistent with urinary excretion characteristics. Ready diffusion of the ester across biological membranes may facilitate eradication of pathogenic organisms in prostatic and spinal fluids.
通过持续静脉输注给予犬氨苄西林或海他西林酯后，测定了血浆、前列腺液和脑脊液中氨苄西林及海他西林甲氧基甲酯的浓度。给予海他西林酯后，前列腺液中氨苄西林与血浆水平的比值更高。药代动力学参数值与尿排泄特征一致。酯类易于透过生物膜，这可能有助于根除前列腺液和脑脊液中的致病微生物。
