• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

An improved synthesis of 4-azido-4-deoxy- and 4-amino-4-deoxy-alpha,alpha-trehalose and their epimers.

作者信息

Bassily R W, el-Sokkary R I, Silwanis B A, Nematalla A S, Nashed M A

机构信息

Department of Chemistry, Faculty of Science, Alexandria University, Egypt.

出版信息

Carbohydr Res. 1993 Feb 1;239:197-207. doi: 10.1016/0008-6215(93)84215-r.

DOI:10.1016/0008-6215(93)84215-r
PMID:8457995
Abstract

The order of esterification of the eight hydroxyl groups of alpha,alpha-trehalose is HO-6.6' > HO-2.2' > HO-3.3' > HO-4.4'. Under the appropriate conditions of benzoylation, the heptabenzoate with HO-4' free was obtained in good yield (58%), along with the octabenzoate and the hexabenzoate having HO-4.4' free. The readily isolated heptabenzoate was a convenient starting material for the synthesis of 4-azido-4-deoxy- (84%) and 4-amino-4-deoxy-alpha-D-galactopyranosyl alpha-D-glucopyranoside, and the heptabenzoate of alpha-D-galactopyranosyl alpha-D-glucopyranoside with HO-4' free, which was used as a synthetic precursor of 4-azido-4-deoxy-alpha-D-glucopyranosyl alpha-D-glucopyranoside and its amino analogue.

摘要

相似文献

1
An improved synthesis of 4-azido-4-deoxy- and 4-amino-4-deoxy-alpha,alpha-trehalose and their epimers.
Carbohydr Res. 1993 Feb 1;239:197-207. doi: 10.1016/0008-6215(93)84215-r.
2
Preparation of 3-amino-3-deoxy derivatives of trehalose and sucrose and their activities.海藻糖和蔗糖的3-氨基-3-脱氧衍生物的制备及其活性。
J Antibiot (Tokyo). 1989 Apr;42(4):585-90. doi: 10.7164/antibiotics.42.585.
3
Synthesis of the allo-analogue of trehalose.海藻糖的异源类似物的合成。
Carbohydr Res. 1976 Jul;49:153-61. doi: 10.1016/s0008-6215(00)83133-x.
4
Synthesis of heparin fragments. A chemical synthesis of the pentasaccharide O-(2-deoxy-2-sulfamido-6-O-sulfo-alpha-D-glucopyranosyl)-(1-4 )-O-(beta-D-glucopyranosyluronic acid)-(1-4)-O-(2-deoxy-2-sulfamido-3,6-di-O-sulfo-alpha-D-glu copyranosyl)-(1-4)-O-(2-O-sulfo-alpha-L-idopyranosyluronic acid)-(1-4)-2-deoxy-2-sulfamido-6-O-sulfo-D-glucopyranose decasodium salt, a heparin fragment having high affinity for antithrombin III.肝素片段的合成。五糖O-（2-脱氧-2-磺酰胺基-6-O-磺基-α-D-吡喃葡萄糖基）-（1→4）-O-（β-D-吡喃葡萄糖醛酸）-（1→4）-O-（2-脱氧-2-磺酰胺基-3,6-二-O-磺基-α-D-吡喃葡萄糖基）-（1→4）-O-（2-O-磺基-α-L-吡喃艾杜糖醛酸）-（1→4）-2-脱氧-2-磺酰胺基-6-O-磺基-D-吡喃葡萄糖十钠盐的化学合成，一种对抗凝血酶III具有高亲和力的肝素片段。
Carbohydr Res. 1986 Mar 15;147(2):221-36. doi: 10.1016/s0008-6215(00)90633-5.
5
Synthesis of neoglycolipids containing a mucin-type core unit.含粘蛋白型核心单元的新糖脂的合成。
Carbohydr Res. 1994 Nov 15;264(2):209-26. doi: 10.1016/s0008-6215(05)80007-2.
6
Synthesis of methyl glycoside derivatives of tri- and penta-saccharides related to the antithrombin III-binding sequence of heparin, employing cellobiose as a key starting-material.以纤维二糖为关键起始原料，合成与肝素抗凝血酶III结合序列相关的三糖和五糖的甲基糖苷衍生物。
Carbohydr Res. 1988 Jan 15;172(1):37-64. doi: 10.1016/s0008-6215(00)90842-5.
7
Pivalates in the selective protection and activation of maltose for the synthesis of sulfated 3-deoxy-maltosyl-(1-->4)-alpha, alpha-trehalose.新戊酸酯在麦芽糖的选择性保护和活化中用于合成硫酸化的3-脱氧麦芽糖基-(1→4)-α,α-海藻糖。
Carbohydr Res. 1997 Jan 2;297(2):163-8. doi: 10.1016/s0008-6215(96)00262-5.
8
Synthesis of KDN-lactotetraosylceramide, KDN-neolactotetraosylceramide, and KDN-Lewis X ganglioside.KDN-乳糖四糖神经酰胺、KDN-新乳糖四糖神经酰胺和KDN-Lewis X神经节苷脂的合成。
Carbohydr Res. 1994 Jun 17;259(2):201-18. doi: 10.1016/0008-6215(94)84058-x.
9
Synthesis of 4-deoxy-D-xylo-hexose and 4-azido-4-deoxy-D-glucose and their effects on lactose synthase.
Carbohydr Res. 1980 Mar 15;81(2):239-47. doi: 10.1016/s0008-6215(00)85655-4.
10
Streptococcus pneumoniae type XIV polysaccharide: synthesis of a repeating branched tetrasaccharide with dioxa-type spacer-arms.肺炎链球菌 XIV 型多糖：具有二氧杂型间隔臂的重复分支四糖的合成
Carbohydr Res. 1986 Aug 1;150:199-212. doi: 10.1016/0008-6215(86)80016-7.

引用本文的文献

1
Benzoylation of Tetrols: A Comparison of Regioselectivity Patterns for and Glycosides of d-Galactose.四醇的苯甲酰化：d-半乳糖苷和苷的区域选择性模式比较。
J Org Chem. 2024 Oct 4;89(19):14090-14097. doi: 10.1021/acs.joc.4c01508. Epub 2024 Sep 12.
2
Fluorinated trehalose analogues for cell surface engineering and imaging of .用于细胞表面工程和成像的氟化海藻糖类似物 。 （原文句子似乎不完整）
Chem Sci. 2024 Aug 12;15(34):13966-75. doi: 10.1039/d4sc00721b.
3
Targeting Persistence through Inhibition of the Trehalose Catalytic Shift.通过抑制海藻糖催化转变来靶向持久性。
ACS Infect Dis. 2024 Apr 12;10(4):1391-1404. doi: 10.1021/acsinfecdis.4c00138. Epub 2024 Mar 14.
4
Degradation-resistant trehalose analogues block utilization of trehalose by hypervirulent Clostridioides difficile.抗降解海藻糖类似物可阻止产毒艰难梭菌利用海藻糖。
Chem Commun (Camb). 2019 Apr 23;55(34):5009-5012. doi: 10.1039/c9cc01300h.
5
Hepatic arginase 2 (Arg2) is sufficient to convey the therapeutic metabolic effects of fasting.肝脏精氨酸酶 2（Arg2）足以传递禁食的治疗代谢效应。
Nat Commun. 2019 Apr 8;10(1):1587. doi: 10.1038/s41467-019-09642-8.
6
Hepatocyte ALOXE3 is induced during adaptive fasting and enhances insulin sensitivity by activating hepatic PPARγ.肝细胞 ALOXE3 在适应性禁食期间被诱导，并通过激活肝 PPARγ 增强胰岛素敏感性。
JCI Insight. 2018 Aug 23;3(16). doi: 10.1172/jci.insight.120794.
7
Tailoring Trehalose for Biomedical and Biotechnological Applications.定制用于生物医学和生物技术应用的海藻糖。
Pure Appl Chem. 2017 Sep;89(9):1223-1249. doi: 10.1515/pac-2016-1025. Epub 2017 Jan 11.
8
Deoxyfluoro-d-trehalose (FDTre) analogues as potential PET probes for imaging mycobacterial infection.脱氧氟代 - d - 海藻糖（FDTre）类似物作为用于成像分枝杆菌感染的潜在正电子发射断层显像（PET）探针。
Org Biomol Chem. 2016 Sep 28;14(36):8598-609. doi: 10.1039/c6ob01734g. Epub 2016 Aug 25.