短暂性前脑缺血后易卒中自发性高血压大鼠海马中内皮素生成增加：组织化学证据
Increased production of endothelins in the hippocampus of stroke-prone spontaneously hypertensive rats following transient forebrain ischemia: histochemical evidence.
作者信息
Yamashita K, Kataoka Y, Niwa M, Shigematsu K, Himeno A, Koizumi S, Taniyama K
机构信息
Department of Pharmacology 2, Nagasaki University School of Medicine, Japan.
出版信息
Cell Mol Neurobiol. 1993 Feb;13(1):15-23. doi: 10.1007/BF00712986.
Abstract
- The effect of transient forebrain ischemia on endothelin-1 (ET-1) and endothelin-3 (ET-3) production in the hippocampus of stroke-prone spontaneously hypertensive rats (SHRSPs) was investigated using immunohistochemical techniques. 2. In SHRSPs subjected to 10-min bilateral carotid occlusion, neuronal degeneration in the CA1 pyramidal cell layer of the hippocampus was detectable at 4 days and remarkable at 7 days after reperfusion. 3. Coinciding with neuronal degeneration, ET-1- and ET-3-like immunoreactivities were intense in the CA1 pyramidal-cell layer, the stratum lacunosum moleculare, and the CA4 subfield of the hippocampus. Almost all of the immunostained cells had morphological characteristics of astrocytes. 4. The possibility that ET has a role in the development of neuronal cell death following transient forebrain ischemia warrants further attention.
摘要
- 采用免疫组织化学技术，研究短暂性前脑缺血对易卒中型自发性高血压大鼠（SHRSPs）海马中内皮素-1（ET-1）和内皮素-3（ET-3）产生的影响。2. 在接受10分钟双侧颈动脉闭塞的SHRSPs中，海马CA1锥体细胞层的神经元变性在再灌注后4天可检测到，7天时明显。3. 与神经元变性同时发生的是，ET-1和ET-3样免疫反应性在海马的CA1锥体细胞层、分子层和CA4亚区强烈。几乎所有免疫染色细胞都具有星形胶质细胞的形态特征。4. ET在短暂性前脑缺血后神经元细胞死亡发展中起作用的可能性值得进一步关注。
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