Melo F, Brandan E
Department of Cell and Molecular Biology, Faculty of Biologycal Sciences, Catholic University of Chile, Santiago.
FEBS Lett. 1993 Mar 22;319(3):249-52. doi: 10.1016/0014-5793(93)80556-a.
We have previously communicated that heparin co-solubilizes the asymmetric form of acetylcholinesterase (AChE) and a dermatan sulfate proteoglycan from the extracellular matrix (ECM) of rat skeletal muscles. In this report we unequivocally demonstrate by biochemical and immunological analyses that the proteoglycan that is solubilized by heparin from rat skeletal muscle ECM corresponds to decorin. These results support the concept for the role of decorin in the ECM organization.
我们之前曾报道过，肝素可使大鼠骨骼肌细胞外基质（ECM）中的不对称形式乙酰胆碱酯酶（AChE）与硫酸皮肤素蛋白聚糖共溶解。在本报告中，我们通过生化和免疫学分析明确证明，肝素从大鼠骨骼肌ECM中溶解出的蛋白聚糖对应于核心蛋白聚糖。这些结果支持了核心蛋白聚糖在ECM组织中作用的概念。
