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醋酸亮丙瑞林与通过定量数字化射线照相术测量的骨矿物质密度

Leuprolide acetate and bone mineral density measured by quantitative digitized radiography.

作者信息

Scialli A R, Jestila K J, Simon J A

机构信息

Department of Obstetrics and Gynecology, Georgetown University Medical Center, Washington, D.C. 20007-2197.

出版信息

Fertil Steril. 1993 Mar;59(3):674-6. doi: 10.1016/s0015-0282(16)55820-8.

DOI:10.1016/s0015-0282(16)55820-8
PMID:8458476
Abstract

Quantitative digitized radiography uses low-energy photons to measure bone density with precision not available in older techniques. Using this method, lumbar spine density was evaluated in 12 women before and after 6 months of therapy with LA. A 2.9% decrement in mean bone density was documented. The reproducibility of quantitative digitized radiography suggests that this small degree of bone mineral loss is a real phenomenon and not an artifact of measurement. The clinical significance of this degree of bone mineral loss has yet to be established.

摘要

定量数字化放射成像使用低能光子来精确测量骨密度,这是早期技术所无法做到的。采用这种方法,对12名女性在接受亮丙瑞林治疗6个月前后的腰椎骨密度进行了评估。结果显示平均骨密度下降了2.9%。定量数字化放射成像的可重复性表明,这种程度较小的骨矿物质流失是一种真实现象,而非测量假象。这种程度的骨矿物质流失的临床意义尚待确定。

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引用本文的文献

1
Long-term effects on bone mineral density and bone metabolism of 6 months' treatment with gonadotropin-releasing hormone analogues in Japanese women: comparison of buserelin acetate with leuprolide acetate.促性腺激素释放激素类似物对日本女性进行6个月治疗后对骨矿物质密度和骨代谢的长期影响:醋酸布舍瑞林与醋酸亮丙瑞林的比较
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2
Leuprorelin. A review of its pharmacology and therapeutic use in prostatic cancer, endometriosis and other sex hormone-related disorders.亮丙瑞林。其药理学及在前列腺癌、子宫内膜异位症和其他性激素相关疾病中的治疗应用综述。
Drugs. 1994 Dec;48(6):930-67. doi: 10.2165/00003495-199448060-00008.