Harding N J, Davies W E
Department of Pharmacology, Medical School, University of Birmingham, UK.
Hear Res. 1993 Feb;65(1-2):211-5. doi: 10.1016/0378-5955(93)90214-l.
The cellular localisation of taurine in the organ of Corti has been established using a monoclonal antibody and confocal fluorescence microscopy. The bulk of the taurine was found in the outer hair cells with very little present in the inner hair cells and supporting structures. The outer hair cells which probably function as an amplification/attenuation gain system, control inner hair cell output to the brain. Taurine is tentatively postulated as being related to calcium fluxes involved in outer hair cell response to sound or olivocochlear bundle stimulation. Other possibilities are also discussed.
利用单克隆抗体和共聚焦荧光显微镜技术已确定了牛磺酸在柯蒂氏器中的细胞定位。发现大部分牛磺酸存在于外毛细胞中，而在内毛细胞和支持结构中含量极少。外毛细胞可能起着放大/衰减增益系统的作用，控制着内毛细胞向大脑的输出。初步推测牛磺酸与外毛细胞对声音或橄榄耳蜗束刺激的反应中涉及的钙通量有关。还讨论了其他可能性。
