Antonini I, Claudi F, Franchetti P, Grifantini M, Martelli S
J Med Chem. 1977 Mar;20(3):447-9. doi: 10.1021/jm00213a024.
The geometrical isomers of the antineoplastic agents 2-formylpyridine and 1-formylisoquinoline thiosemicarbazones were synthesized and their structure was studied by spectroscopic methods. It was found that the compounds previously described in the literature and tested for carcinostatic activity were isomers with E configuration which probably contained minor amounts of Z isomers.
合成了抗肿瘤药物2-甲酰基吡啶和1-甲酰基异喹啉硫代半卡巴腙的几何异构体，并通过光谱方法研究了它们的结构。结果发现，文献中先前描述并测试过抑癌活性的化合物是E构型的异构体，可能含有少量Z异构体。
