Sato T, Tadokoro M, Kaba H, Saito H, Seto K, Takatsuji H
Department of Physiology, Kochi Medical School, Japan.
J Appl Physiol (1985). 1993 Feb;74(2):545-8. doi: 10.1152/jappl.1993.74.2.545.
The presence of endogenous digitalis-like factors in the central nervous system suggests their functional significance in the central nervous system. Three-day infusions of three-stepped doses of the digitalis agent ouabain (1-100 ng.kg body wt-1.h-1) into the lateral cerebral ventricle of freely moving rats caused a dose-dependent increase in the number of central-apneic episodes during rapid-eye-movement sleep without affecting the time spent in rapid-eye-movement sleep or basic respiratory rate. These results suggest that endogenous digitalis-like factors may be involved in the genesis of central sleep apneas.
中枢神经系统中内源性洋地黄样因子的存在表明了它们在中枢神经系统中的功能意义。向自由活动大鼠的侧脑室中连续三天输注三个阶梯剂量的洋地黄制剂哇巴因（1 - 100纳克·千克体重⁻¹·小时⁻¹），导致快速眼动睡眠期间中枢性呼吸暂停发作次数呈剂量依赖性增加，而不影响快速眼动睡眠时长或基础呼吸频率。这些结果表明，内源性洋地黄样因子可能参与中枢性睡眠呼吸暂停的发生。
