Sato T, Saito H, Seto K, Takatsuji H
Department of Physiology, Kochi Medical School, Japan.
Am J Physiol. 1990 Aug;259(2 Pt 2):R282-7. doi: 10.1152/ajpregu.1990.259.2.R282.
We studied the mechanisms of occurrences of apneas and bradyarrhythmias during sleep in five Wistar-Kyoto rats. We recorded electroencephalograms, electrocardiograms, chest wall movement, and diaphragmatic electromyograms (EMGdi) for three continuous days in each freely moving rat and demonstrated that: 1) 99% of the apneas and 99% of the bradyarrhythmias occurred during paradoxical sleep (PS), 2) 98% of the apneas were due to spontaneous cessations of respiratory drive, 3) the percentages among apneas accompanied with bradyarrhythmias were only about 30% and independent of the apneic durations, 4) every autoregressive power spectrum contained two significant components in the ranges of 50-80 and 110-140 Hz, which would be analogous to high-frequency oscillations postulated to originate in the synaptic input to the phrenic motoneurons from respiratory centers, and 5) spectral patterns of EMGdi signals varied with sleep states. These results suggest that "PS-related" neural activity modulating central respiratory output is important in inducing apneas and promoting bradyarrhythmias.
我们研究了五只Wistar-Kyoto大鼠睡眠期间呼吸暂停和心律失常的发生机制。我们在每只自由活动的大鼠中连续三天记录脑电图、心电图、胸壁运动和膈肌肌电图（EMGdi），结果表明：1）99%的呼吸暂停和99%的心律失常发生在异相睡眠（PS）期间；2）98%的呼吸暂停是由于呼吸驱动的自发停止；3）伴有心律失常的呼吸暂停比例仅约为30%，且与呼吸暂停持续时间无关；4）每个自回归功率谱在50 - 80Hz和110 - 140Hz范围内包含两个显著成分，这类似于假定起源于呼吸中枢向膈运动神经元的突触输入的高频振荡；5）EMGdi信号的频谱模式随睡眠状态而变化。这些结果表明，调节中枢呼吸输出的“PS相关”神经活动在诱发呼吸暂停和促进心律失常方面很重要。
