Bujan L, Mieusset R, Audran F, Lumbroso S, Sultan C
Laboratoire de Biologie de la Reproduction, Hôpital La Grave, Toulouse, France.
Hum Reprod. 1993 Jan;8(1):74-7. doi: 10.1093/oxfordjournals.humrep.a137878.
Seminal hormonal patterns in fertile and infertile men were investigated. Follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin, testosterone and oestradiol were assessed by radioimmunoassay, and dehydroepiandrosterone sulphate (DHAS) by bioluminescence assay, on blood and seminal plasma of 23 fertile men and 83 infertile men. For fertile men, mean FSH, LH, testosterone and DHAS concentrations were lower and mean oestradiol was higher in seminal than in blood plasma; prolactin did not differ. For infertile men, mean seminal FSH and LH showed a moderate but significant increase compared with fertile men; testosterone, DHAS and prolactin did not differ but mean seminal oestradiol was significantly increased. Of the infertile men, 53% had seminal oestradiol concentration above the 90th percentile value for fertile men. The meaning of this seminal oestradiol increase is unclear since it is not known whether it is the cause or the consequence of the alteration of spermatogenesis in infertile men. Further studies are required to explore the possible therapeutic implications.
对有生育能力和不育男性的精液激素模式进行了研究。通过放射免疫分析法对23名有生育能力的男性和83名不育男性的血液和精浆中的促卵泡激素（FSH）、促黄体生成素（LH）、催乳素、睾酮和雌二醇进行了评估，并通过生物发光分析法对硫酸脱氢表雄酮（DHAS）进行了评估。对于有生育能力的男性，精浆中的FSH、LH、睾酮和DHAS平均浓度低于血浆，而雌二醇平均浓度高于血浆；催乳素无差异。对于不育男性，与有生育能力的男性相比，精浆中的FSH和LH平均有中度但显著的升高；睾酮、DHAS和催乳素无差异，但精浆中的雌二醇平均显著升高。在不育男性中，53%的人精浆中雌二醇浓度高于有生育能力男性的第90百分位数。这种精浆中雌二醇升高的意义尚不清楚，因为不知道它是不育男性精子发生改变的原因还是结果。需要进一步的研究来探讨其可能的治疗意义。
