Weil S C, Rose V L
Am J Clin Pathol. 1986 Feb;85(2):176-9. doi: 10.1093/ajcp/85.2.176.
An unusual myelodysplastic syndrome with similar features in two patients is described. The entity is characterized by a maturation arrest at the myelocyte stage, strikingly clumpy chromatin, and a clinical course marked primarily by difficulties caused by anemia and thrombocytopenia. Electron microscopic description of the characteristic abnormal clumpy chromatin cells is included. While the disorder is unquestionably a myelodysplastic syndrome, it is clearly distinct from chronic myelogenous leukemia, chronic myelomonocytic leukemia, and the spectrum of refractory anemias with excess blasts.
本文描述了两名具有相似特征的罕见骨髓增生异常综合征患者。该病症的特点是在髓细胞阶段成熟停滞、染色质显著结块，以及主要以贫血和血小板减少引起的困难为特征的临床病程。文中还包括了对特征性异常结块染色质细胞的电子显微镜描述。虽然该病症无疑是一种骨髓增生异常综合征，但它明显不同于慢性粒细胞白血病、慢性粒单核细胞白血病以及伴有过多原始细胞的难治性贫血谱系。
