Diver M J
Department of Clinical Chemistry, University of Liverpool, Alder Hey Hospital, U.K.
J Endocrinol. 1993 Feb;136(2):327-30. doi: 10.1677/joe.0.1360327.
The effect of supraphysiological levels of free fatty acids (FFA) on the binding of testosterone to sex-hormone binding globulin (SHBG) and on non-SHBG binding in both male plasma and plasma from pregnant women was studied. Six FFAs were added to plasma as individual acids. No alteration in testosterone binding to SHBG could be demonstrated with any of the FFAs in either male plasma or plasma from pregnant women. When the same plasma was heated to destroy SHBG binding, a highly significant (P < 0.01) increase in non-SHBG binding was seen in both male plasma and plasma from pregnant women when the unsaturated FFAs oleic, linoleic and linolenic acids were added. No significant difference was demonstrated with the saturated FFAs, palmitic, stearic and arachidic acids.
研究了超生理水平的游离脂肪酸（FFA）对睾酮与性激素结合球蛋白（SHBG）结合以及对男性血浆和孕妇血浆中非SHBG结合的影响。将六种FFA作为单个酸添加到血浆中。在男性血浆或孕妇血浆中，任何一种FFA均未显示出睾酮与SHBG结合的改变。当将相同的血浆加热以破坏SHBG结合时，添加不饱和FFA油酸（oleic）、亚油酸（linoleic）和亚麻酸（linolenic）时，男性血浆和孕妇血浆中的非SHBG结合均显著增加（P < 0.01）。饱和FFA棕榈酸（palmitic）、硬脂酸（stearic）和花生酸（arachidic）未显示出显著差异。
