Mooradian A D, Pamplona D M, Viosca S P, Korenman S G
Department of Medicine, Veterans Administration Medical Center, Sepulveda, CA 91343.
J Steroid Biochem. 1988 Mar;29(3):369-70. doi: 10.1016/0022-4731(88)90040-4.
Free fatty acids (FFA) are known to interfere with the binding of thyroid hormone and estrogens to circulating proteins, but their effect on androgen binding is unknown. The effect of linoleic, oleic and palmitic acids at physiological concentrations on the binding of testosterone (T) and dihydrotestosterone (DHT) to circulating proteins was evaluated in vitro, using equilibrium dialysis and ammonium sulfate precipitation techniques. The results indicate that FFA can inhibit T binding to albumin and SHBG. They also can inhibit DHT binding to albumin, whereas DHT binding to SHBG is not altered, suggesting that FFA at physiological concentrations may be important regulators of bioavailability of T to tissues.
已知游离脂肪酸（FFA）会干扰甲状腺激素和雌激素与循环蛋白的结合，但其对雄激素结合的影响尚不清楚。采用平衡透析和硫酸铵沉淀技术，在体外评估了生理浓度的亚油酸、油酸和棕榈酸对睾酮（T）和双氢睾酮（DHT）与循环蛋白结合的影响。结果表明，游离脂肪酸可抑制T与白蛋白和性激素结合球蛋白（SHBG）的结合。它们还可抑制DHT与白蛋白的结合，而DHT与SHBG的结合未发生改变，这表明生理浓度的游离脂肪酸可能是T向组织生物利用度的重要调节因子。
