胸腺上皮诱导组织特异性耐受。
Thymus epithelium induces tissue-specific tolerance.
作者信息
Bonomo A, Matzinger P
机构信息
Laboratory for Cellular and Molecular Immunology, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland 20892.
出版信息
J Exp Med. 1993 Apr 1;177(4):1153-64. doi: 10.1084/jem.177.4.1153.
Abstract
Most current models of T cell development include a positive selection step in the thymus that occurs when T cells interact with thymic epithelium and a negative selection step after encounters with bone marrow-derived cells. We show here that developing T cells are tolerized when they recognize antigens expressed by thymic epithelium, that the tolerance is tissue specific, and that it can occur by deletion of the reactive T cells.
摘要
目前大多数T细胞发育模型包括胸腺中的阳性选择步骤，该步骤发生在T细胞与胸腺上皮相互作用时，以及在与骨髓来源的细胞接触后的阴性选择步骤。我们在此表明，发育中的T细胞在识别胸腺上皮表达的抗原时会产生耐受性，这种耐受性具有组织特异性，并且可以通过反应性T细胞的缺失而发生。
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本文引用的文献
1
Studies on tolerance of the Y chromosome antigen in mice.小鼠Y染色体抗原耐受性的研究。
J Immunol. 1960 Jul;85:14-26.
2
Genes and antibodies.基因与抗体。
Science. 1959 Jun 19;129(3364):1649-53. doi: 10.1126/science.129.3364.1649.
3
Incomplete tolerance to MHC antigens in irradiation chimeras: implications for MHC restriction and self tolerance.辐射嵌合体中对MHC抗原的不完全耐受：对MHC限制和自身耐受的影响。
Immunol Rev. 1981;58:25-36. doi: 10.1111/j.1600-065x.1981.tb00348.x.
4
Transplantation biology and immunogenetics of murine skin-specific (Sk) alloantigens.小鼠皮肤特异性（Sk）同种异体抗原的移植生物学与免疫遗传学
Transplant Proc. 1980 Sep;12(3 Suppl 1):100-6.
5
Successful transplantation across major histocompatibility barrier of deoxyguanosine-treated embryonic thymus expressing class II antigens.经脱氧鸟苷处理的表达II类抗原的胚胎胸腺跨越主要组织相容性屏障的成功移植。
Nature. 1984;310(5974):231-3. doi: 10.1038/310231a0.
6
Thymocytes appear to ignore class I major histocompatibility complex antigens expressed on thymus epithelial cells.胸腺细胞似乎会忽略胸腺上皮细胞上表达的I类主要组织相容性复合体抗原。
Eur J Immunol. 1984 Nov;14(11):1048-52. doi: 10.1002/eji.1830141116.
7
A one-receptor view of T-cell behaviour.
Nature. 1981 Aug 6;292(5823):497-501. doi: 10.1038/292497a0.
8
Effect of deoxyguanosine on lymphopoiesis in the developing thymus rudiment in vitro: application in the production of chimeric thymus rudiments.脱氧鸟苷对体外发育的胸腺原基中淋巴细胞生成的影响：在嵌合胸腺原基生产中的应用。
Eur J Immunol. 1982 Jul;12(7):583-7. doi: 10.1002/eji.1830120710.
9
Differential survival of skin and heart allografts in radiation chimaeras provides further evidence for Sk histocompatibility antigen.
Nature. 1974 Apr 26;248(5451):796-7. doi: 10.1038/248796a0.
10
Tolerance of Sk-incompatible skin grafts.
Nature. 1973 Aug 17;244(5416):441-2. doi: 10.1038/244441a0.
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