Ghost Lab, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, Bethesda, MD, United States.
Front Immunol. 2022 Nov 3;13:864633. doi: 10.3389/fimmu.2022.864633. eCollection 2022.
For decades, the main question immunologists have asked about autoimmunity is "what causes a break in self-tolerance?" We have not found good answers to that question, and I believe we are still so ignorant because it's the wrong question. Rather than a break in self-tolerance, I suggest that many autoimmune diseases might be due to defects in normal tissue physiology.
几十年来,免疫学家主要研究的自身免疫问题是“是什么导致了自身耐受的打破?”我们还没有找到这个问题的答案,我认为我们之所以如此无知,是因为这是一个错误的问题。我认为,许多自身免疫性疾病可能不是由于自身耐受的打破,而是由于正常组织生理学的缺陷所致。