Arai K, Joko M, Kagebayashi Y, Tsumatani K, Kimura S, Sasaki K, Samma S, Okajima E, Nakaoka S
Department of Urology, Nara Prefectural Nara Hospital.
Jpn J Clin Oncol. 1993 Feb;23(1):74-7.
A case of primary malignant melanoma of the female urethra is presented. A 65-year-old Japanese woman was referred with dysuria and urethral bleeding. A hemorrhagic blue-black tumor, 3 cm in diameter, was diagnosed as a malignant melanoma by urinary cytology and biopsy. In spite of radical surgery followed by adjuvant immunochemotherapy with beta interferon, dacarbazine, nimustine and vincristine (IFN beta-DAV), the patient died of the disease one year after surgery because of lung metastasis which developed six months after diagnosis. The regional lymph nodes were not involved. In the present paper, we have briefly discussed the diagnostic value of cytological examination for this condition, as well as biopsy, with regard to the risk of hematogeneous tumor spread.
本文报道一例女性尿道原发性恶性黑色素瘤病例。一名65岁的日本女性因排尿困难和尿道出血前来就诊。通过尿液细胞学检查和活检，诊断出一个直径3厘米的出血性蓝黑色肿瘤为恶性黑色素瘤。尽管进行了根治性手术，随后采用β干扰素、达卡巴嗪、尼莫司汀和长春新碱（IFNβ-DAV）进行辅助免疫化疗，但患者在手术后一年因疾病死亡，原因是诊断后六个月出现了肺转移。区域淋巴结未受累。在本文中，我们简要讨论了针对这种情况的细胞学检查以及活检在血行性肿瘤播散风险方面的诊断价值。
