Zioupos P, Barbenel J C, Lowe G D, MacRury S
Bioengineering Unit, University of Strathclyde, Glasgow.
J Biomed Eng. 1993 Mar;15(2):155-8. doi: 10.1016/0141-5425(93)90048-4.
Diabetes mellitus is associated with circulatory abnormalities. The blood flow in the skin of the dorsum of the foot and haemorheological variables were measured in 36 subjects. They were divided into three equal groups of diabetic patients: those with neuropathy, and both age and sex matched non-diabetic subjects; all were characterized by age, duration of diabetes and blood biochemistry. High and low shear rate blood viscosities were measured; aggregation was characterized using a Myrerene Aggregometer. The microcirculation in the skin of the dorsum of the foot was measured using a laser Doppler flowmeter. Measurements were made at room temperature with the subjects supine with the leg horizontal, and then with the lower leg vertical; the measurements were repeated at 42 degrees C. Both diabetic groups had significantly increased low shear whole blood viscosity compared with normal subjects. The aggregation index was significantly greater in diabetic neuropaths than normal subjects. There were significant differences in the depth of vasomotor activity between the three groups, with the diabetic neuropaths commonly showing no motor activity at room temperature. The only significant correlations were between equilibrium laser Doppler values with the limb horizontal and both the low and high shear whole blood viscosities.
糖尿病与循环系统异常有关。对36名受试者的足背皮肤血流和血液流变学变量进行了测量。他们被分为三组人数相等的糖尿病患者：患有神经病变的患者，以及年龄和性别匹配的非糖尿病受试者；所有受试者均以年龄、糖尿病病程和血液生化指标为特征。测量了高、低剪切率下的血液粘度；使用Myrerene凝集仪对凝集特性进行了表征。使用激光多普勒血流仪测量了足背皮肤的微循环。测量在室温下进行，受试者仰卧，腿部水平放置，然后小腿垂直；在42摄氏度时重复测量。与正常受试者相比，两个糖尿病组的低剪切全血粘度均显著增加。糖尿病神经病变患者的凝集指数显著高于正常受试者。三组之间血管舒缩活动深度存在显著差异，糖尿病神经病变患者在室温下通常无运动活动。唯一显著的相关性是肢体水平时的平衡激光多普勒值与低、高剪切全血粘度之间的相关性。
